Prp19: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Aaron Smith (talk | contribs) |
Aaron Smith (talk | contribs) No edit summary |
||
| Line 6: | Line 6: | ||
=Structure= | =Structure= | ||
In Humans, the gene which is homologous to that of PRP19 in ''S. cerevisiae'' is located on chromosome 11 (11q12.2).<ref>"Entrez Gene: PRPF19 PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27339.</ref> The protein is 503 amino acid residues in length and | In Humans, the gene which is homologous to that of PRP19 in ''S. cerevisiae'' is located on chromosome 11 (11q12.2).<ref>"Entrez Gene: PRPF19 PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27339.</ref> The protein is 503 amino acid residues in length and forms a tetramer with a centrally coiled domain<Ref>PMID:16388587</ref>. Two majors functional domains have been identified, the WD40 domain and the U Box domain<ref>pmid:20462492</ref> | ||
| Line 12: | Line 12: | ||
[[Image:2bay_small.jpg]] This is a CPK representation of the U Box Domain of PRP19 | [[Image:2bay_small.jpg]] This is a CPK coloured representation of the U Box Domain of PRP19 | ||
U-Box proteins are a class of | |||
=Role in Splicing= | =Role in Splicing= | ||
