Prp19: Difference between revisions
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[[Image:3LRV_-_secondary_small.jpg]] WD40 domains can be found throughout a large variety of organisms and are highly abundant in eukaryotic proteins.<ref>http://pawsonlab.mshri.on.ca/index.php?option=com_content&task=view&Itemid=64&id=190</ref> | [[Image:3LRV_-_secondary_small.jpg]] WD40 domains can be found throughout a large variety of organisms and are highly abundant in eukaryotic proteins. WD40 domains can have several functions including cell cycle control, involvement in signal transduction, assembly of the cytoskeleton, gene transcriptional activiation and pre mRNA processing. Conserved repeats ~40 residues long, consisting of tryptophan and aspartic acid residues, form Beta Propeller structures which can be seen in the image to the left as well as in the default scene image. The default scene also shows 4 SO4 molecules binding which help to activate the complex. Beta Propeller repeats can often as as platforms for binding of other proteins or ligands. <ref>http://pawsonlab.mshri.on.ca/index.php?option=com_content&task=view&Itemid=64&id=190</ref> | ||
=Role in Splicing= | =Role in Splicing= | ||
