Prp19: Difference between revisions
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Studies have found that PRP19 associates with the spliceosome around the time that the U4 snRNP disassociates from the complex. This is thought to be evidence towards PRP19's involvement in the conformational rearrangement that occurs at this stage of the splicing process.<ref name ="functional"/> Other evidence suggests that PRP19 acts to stabilize the association of U5 and U6 with the active spliceosome. Researchers have also suggested that PRP19 is part of a heteromeric complex which is comprised of at least eight different proteins,coined the nineteen complex or NTC.<ref name ="2004EMBO">PMID:15175653</ref> There is also evidence that PRP19 may be part of an even larger complex consisting of the U2, U5 and U6 snRNA as well as many other proteins.<ref name="ohi">PMID:12088152</ref> | Studies have found that PRP19 associates with the spliceosome around the time that the U4 snRNP disassociates from the complex. This is thought to be evidence towards PRP19's involvement in the conformational rearrangement that occurs at this stage of the splicing process.<ref name ="functional"/> Other evidence suggests that PRP19 acts to stabilize the association of U5 and U6 with the active spliceosome. Researchers have also suggested that PRP19 is part of a heteromeric complex which is comprised of at least eight different proteins,coined the nineteen complex or NTC.<ref name ="2004EMBO">PMID:15175653</ref> There is also evidence that PRP19 may be part of an even larger complex consisting of the U2, U5 and U6 snRNA as well as many other proteins.<ref name="ohi">PMID:12088152</ref> | ||
=The Nineteen Complex= | |||
=References= | =References= | ||
<references /> | <references /> | ||
