Sandbox Reserved 321: Difference between revisions
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=Structure of InhA= | =Structure of InhA= | ||
The inhA enzyme <scene name='Sandbox_Reserved_321/Structural_progression_1/1'>(go to original orientation)</scene> of ''M. tuberculosis'' is a homotetramer composed of a repeating subunit comprised of a single domain with a [http://en.wikipedia.org/wiki/Rossmann_fold Rossmann Fold] in the core that provides a NADH binding site<ref name ="crystallographic studies"/>. The single domain can be broken down into two substructures that are connected by short peptide loop<ref name ="making drugs for inhA"/><ref name ="crystallographic studies">PMID:17588773</ref>. | The inhA enzyme <scene name='Sandbox_Reserved_321/Structural_progression_1/1'>(go to original orientation)</scene> of ''M. tuberculosis'' is a homotetramer composed of a repeating subunit comprised of a single domain with a [http://en.wikipedia.org/wiki/Rossmann_fold Rossmann Fold] in the core that provides a NADH binding site<ref name ="crystallographic studies"/>. The single domain can be broken down into two substructures that are connected by short peptide loop<ref name ="making drugs for inhA"/><ref name ="crystallographic studies">PMID:17588773</ref>. The overall structure exhibits α/β folding of a series of α strands flanking a central β sheet of multiple parallel β strands<ref name ="crystallographic studies"/>. | ||
<Structure load='2h9i' size='250' frame='true' align='left' caption='Momomeric subunit of inhA' scene='Sandbox_Reserved_321/Structural_progresion/1' /> | <Structure load='2h9i' size='250' frame='true' align='left' caption='Momomeric subunit of inhA' scene='Sandbox_Reserved_321/Structural_progresion/1' /> | ||
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*[[1ve7]] – ApAARE+p-nitrophenyl phosphate<br /> | *[[1ve7]] – ApAARE+p-nitrophenyl phosphate<br /> | ||
*[[1i2z]] - EcENR+NAD+imidazole derivative<br /> | *[[1i2z]] - EcENR+NAD+imidazole derivative<br /> | ||
InhA can also be classified into a family of short chain dehydrogenase/reductases (SDR). This family consists of proteins exhibiting a central core with a Rossmann fold that contains a NADH binding site. | |||
=Additional Resources= | =Additional Resources= | ||
