Prp24: Difference between revisions

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== Functional Interactions ==

Prp24 is part of the normal U6 snRNP, along with seven [http://en.wikipedia.org/wiki/Lsm Lsm proteins] (Fig 3)<ref name="Brow review"/>. After interaction with the U4 snRNP to form the U4/U6 di-snRNP, Prp24 departs from the di-snRNP before the addition of U5 to form the tri-snRNP U4/U6.U5 <ref name="Brow review"/>. Through many studies, it has been shown that Prp24 interacts extensively with specific sites on U6, as well with the Lsm protein ring on the 3' terminal end of the U6 snRNA. [[Image:U6_snRNP.jpg frame~~="true" caption="~~Figure 3. Proposed secondary structure of U6 snRNP, with Prp24 stabilizing a large internal bulge on the central stem and the seven Lsm proteins forming a ring around the 3' end of the U6 snRNA (after Karaduman et al. 2006 <ref name="Karaduman2006"/>)" ]]

Prp24 is part of the normal U6 snRNP, along with seven [http://en.wikipedia.org/wiki/Lsm Lsm proteins] (Fig 3)<ref name="Brow review"/>. After interaction with the U4 snRNP to form the U4/U6 di-snRNP, Prp24 departs from the di-snRNP before the addition of U5 to form the tri-snRNP U4/U6.U5 <ref name="Brow review"/>. Through many studies, it has been shown that Prp24 interacts extensively with specific sites on U6, as well with the Lsm protein ring on the 3' terminal end of the U6 snRNA. [[Image:U6_snRNP.jpg |frame|left|Figure 3. Proposed secondary structure of U6 snRNP, with Prp24 stabilizing a large internal bulge on the central stem and the seven Lsm proteins forming a ring around the 3' end of the U6 snRNA (after Karaduman et al. 2006 <ref name="Karaduman2006"/>) ]]

=== U6 snRNA and U4/U6 snRNP ===

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 == Functional Interactions ==
-Prp24 is part of the normal U6 snRNP, along with seven [http://en.wikipedia.org/wiki/Lsm Lsm proteins] (Fig 3)<ref name="Brow review"/>.  After interaction with the U4 snRNP to form the U4/U6 di-snRNP, Prp24 departs from the di-snRNP before the addition of U5 to form the tri-snRNP U4/U6.U5 <ref name="Brow review"/>.  Through many studies, it has been shown that Prp24 interacts extensively with specific sites on U6, as well with the Lsm protein ring on the 3' terminal end of the U6 snRNA. [[Image:U6_snRNP.jpg frame="true" caption="Figure 3.  Proposed secondary structure of U6 snRNP, with Prp24 stabilizing a large internal bulge on the central stem and the seven Lsm proteins forming a ring around the 3' end of the U6 snRNA (after Karaduman et al. 2006 <ref name="Karaduman2006"/>)" ]]
+Prp24 is part of the normal U6 snRNP, along with seven [http://en.wikipedia.org/wiki/Lsm Lsm proteins] (Fig 3)<ref name="Brow review"/>.  After interaction with the U4 snRNP to form the U4/U6 di-snRNP, Prp24 departs from the di-snRNP before the addition of U5 to form the tri-snRNP U4/U6.U5 <ref name="Brow review"/>.  Through many studies, it has been shown that Prp24 interacts extensively with specific sites on U6, as well with the Lsm protein ring on the 3' terminal end of the U6 snRNA. [[Image:U6_snRNP.jpg |frame|left|Figure 3.  Proposed secondary structure of U6 snRNP, with Prp24 stabilizing a large internal bulge on the central stem and the seven Lsm proteins forming a ring around the 3' end of the U6 snRNA (after Karaduman et al. 2006 <ref name="Karaduman2006"/>) ]]
 === U6 snRNA and U4/U6 snRNP ===