Sandbox Reserved 338: Difference between revisions

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==Introduction==

A glycogen-debranching enzyme (GDE) is one of the enzymes associated with the breakdown of glycogen <ref name="Woo">PMID: 18703518 </ref>. The majority of debranching enzymes belong to the GH13 (glycoside hydrolase 13) family <ref name="GH13"> PMID: 17085431 </ref>, and they may further be separated into two main groups based on function <ref name="Woo" />. For example, in mammals and yeast, the GDE ~~possess~~ two functions; both α-1,6-glycosidase and α-1,4-transferase activity, and thus catalyzes two successive reactions in the transfer of glycogen branches <ref name="Woo" />. In bacteria and plants, however, the debranching of glycogen is carried out by two different enzymes, where one possess α-1,6-glycosidase activity and the other possesses α-1,4-transferase activity, but not both <ref name="pullulanase"> PMID: 19465663 </ref>. For example, isoamylases and pullulanases carry out the α-1,6-glycosidic bond hydrolyzing activity <ref name="rice"> PMID: 10517831 </ref>, while glucosyltransferases carry out the α-1,4-transferase activity <ref name="GH13"/>.

A glycogen-debranching enzyme (GDE) is one of the enzymes associated with the breakdown of glycogen <ref name="Woo">PMID: 18703518 </ref>. The majority of debranching enzymes belong to the GH13 (glycoside hydrolase 13) family <ref name="GH13"> PMID: 17085431 </ref>, and they may further be separated into two main groups based on function <ref name="Woo" />. For example, in mammals and yeast, the GDE possesses two functions; both α-1,6-glycosidase and α-1,4-transferase activity, and thus catalyzes two successive reactions in the transfer of glycogen branches <ref name="Woo" />. In bacteria and plants, however, the debranching of glycogen is carried out by two different enzymes, where one possess α-1,6-glycosidase activity and the other possesses α-1,4-transferase activity, but not both <ref name="pullulanase"> PMID: 19465663 </ref>. For example, isoamylases and pullulanases carry out the α-1,6-glycosidic bond hydrolyzing activity <ref name="rice"> PMID: 10517831 </ref>, while glucosyltransferases carry out the α-1,4-transferase activity <ref name="GH13"/>.

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Sandbox Reserved 338: Difference between revisions

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 ==Introduction==
-A glycogen-debranching enzyme (GDE) is one of the enzymes associated with the breakdown of glycogen <ref name="Woo">PMID: 18703518 </ref>. The majority of debranching enzymes belong to the GH13 (glycoside hydrolase 13) family <ref name="GH13"> PMID: 17085431 </ref>, and they may further be separated into two main groups based on function <ref name="Woo" />. For example, in mammals and yeast, the GDE possess two functions; both α-1,6-glycosidase and α-1,4-transferase activity, and thus catalyzes two successive reactions in the transfer of glycogen branches <ref name="Woo" />. In bacteria and plants, however, the debranching of glycogen is carried out by two different enzymes, where one possess α-1,6-glycosidase activity and the other possesses α-1,4-transferase activity, but not both <ref name="pullulanase"> PMID: 19465663 </ref>. For example, isoamylases and pullulanases carry out the α-1,6-glycosidic bond hydrolyzing activity <ref name="rice"> PMID: 10517831 </ref>, while glucosyltransferases carry out the α-1,4-transferase activity <ref name="GH13"/>.
+A glycogen-debranching enzyme (GDE) is one of the enzymes associated with the breakdown of glycogen <ref name="Woo">PMID: 18703518 </ref>. The majority of debranching enzymes belong to the GH13 (glycoside hydrolase 13) family <ref name="GH13"> PMID: 17085431 </ref>, and they may further be separated into two main groups based on function <ref name="Woo" />. For example, in mammals and yeast, the GDE possesses two functions; both α-1,6-glycosidase and α-1,4-transferase activity, and thus catalyzes two successive reactions in the transfer of glycogen branches <ref name="Woo" />. In bacteria and plants, however, the debranching of glycogen is carried out by two different enzymes, where one possess α-1,6-glycosidase activity and the other possesses α-1,4-transferase activity, but not both <ref name="pullulanase"> PMID: 19465663 </ref>. For example, isoamylases and pullulanases carry out the α-1,6-glycosidic bond hydrolyzing activity <ref name="rice"> PMID: 10517831 </ref>, while glucosyltransferases carry out the α-1,4-transferase activity <ref name="GH13"/>.
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