Sandbox Reserved 325: Difference between revisions
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=Chorismate Mutase= | =Chorismate Mutase= | ||
==Introduction== | ==Introduction== | ||
The gene Rv1885c from ''Mycobacteria tuberculosis'' encodes for a non-functional chorismate mutase (*MtCM)<ref name="pizza" />. This non-functional mutase has a 33-amino-acid cleavable sequence <ref name="pizza" />. Chorismate mutase is a vital enzyme in the shikimate pathway, which allows for the synthesis of tryptophan, tyrosine, and phenylalanine <ref name="pizza" />. This protein acts at the first branch point of the shikimate pathway, making it a regulating step in the conversion of prephenate from chorismate<ref name="CMW2"> PMID: | The gene Rv1885c from ''Mycobacteria tuberculosis'' encodes for a non-functional chorismate mutase (*MtCM)<ref name="pizza" />. This non-functional mutase has a 33-amino-acid cleavable sequence <ref name="pizza" />. Chorismate mutase is a vital enzyme in the shikimate pathway, which allows for the synthesis of tryptophan, tyrosine, and phenylalanine <ref name="pizza" />. This protein acts at the first branch point of the shikimate pathway, making it a regulating step in the conversion of prephenate from chorismate<ref name="CMW2"> PMID:11481470 </ref>. | ||
Chorismate mutase provides a 2x10<sup>6</sup> fold increase in the rate of reaction in comparision to the uncatalyzed reaction <ref > P.D. Lyne, A.J. Mulholland, W.G. Richards. Insights into chorismate mutase catalysis from a combined qm/mm simulation of the enzyme reaction. Journal of the American Chemistry Society. 1995 117(45):11345-11350</ref>. | Chorismate mutase provides a 2x10<sup>6</sup> fold increase in the rate of reaction in comparision to the uncatalyzed reaction <ref > P.D. Lyne, A.J. Mulholland, W.G. Richards. Insights into chorismate mutase catalysis from a combined qm/mm simulation of the enzyme reaction. Journal of the American Chemistry Society. 1995 117(45):11345-11350</ref>. | ||
