Sandbox Reserved 344: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 3: | Line 3: | ||
<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | <!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
{{STRUCTURE_2pl1|PDB=2pl1|SCENE=}} | |||
= | =Introduction= | ||
PhoP is a cytoplasmic response regulator from the two component system PhoP/PhoQ. This system responds mainly to changes in extracellular Mg2+ concentration and is an important trigger for gram-negative bacteria such as Escherichia coli and Salmonella enterica to become virulent. PhoQ, located across the inner membrane, responds to low Mg2+ concentration by phosphorylating PhoP. Gene regulation and other two component systems respond to the phosphorylated PhoP. Gene regulation is achieved by increased affinity of the homodimer to the PhoP box, a tandem repeat promoter. The response is organism specific but generally involves survival in low Mg2+ environments and virulence. | PhoP is a cytoplasmic response regulator from the two component system PhoP/PhoQ. This system responds mainly to changes in extracellular Mg2+ concentration and is an important trigger for gram-negative bacteria such as Escherichia coli and Salmonella enterica to become virulent. PhoQ, located across the inner membrane, responds to low Mg2+ concentration by phosphorylating PhoP. Gene regulation and other two component systems respond to the phosphorylated PhoP. Gene regulation is achieved by increased affinity of the homodimer to the PhoP box, a tandem repeat promoter. The response is organism specific but generally involves survival in low Mg2+ environments and virulence. | ||
| Line 54: | Line 54: | ||
S1.1.1.1 | S1.1.1.1 | ||
