3ny6: Difference between revisions
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{{STRUCTURE_3ny6| PDB=3ny6 | SCENE= }} | {{STRUCTURE_3ny6| PDB=3ny6 | SCENE= }} | ||
===Catalytic fragment of cholix toxin from vibrio cholerae in complex with inhibitor V30=== | ===Catalytic fragment of cholix toxin from vibrio cholerae in complex with inhibitor V30=== | ||
{{ABSTRACT_PUBMED_21135177}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/Q5EK40_VIBCH Q5EK40_VIBCH]] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref> | |||
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:021135177</ref><references group="xtra"/><references/> | ||
[[Category: Vibrio cholerae]] | [[Category: Vibrio cholerae]] | ||
[[Category: Jorgensen, R.]] | [[Category: Jorgensen, R.]] | ||
[[Category: Merrill, A R.]] | [[Category: Merrill, A R.]] | ||
[[Category: Adp-ribosyl transferase]] | |||
[[Category: Alpha-beta complex]] | |||
[[Category: Nad+ binding]] | |||
[[Category: Transferase]] | |||
[[Category: Transferase-transferase inhibitor complex]] | |||