3qi2: Difference between revisions

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'''Unreleased structure'''
[[Image:3qi2.png|left|200px]]


The entry 3qi2 is ON HOLD until Paper Publication
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{{STRUCTURE_3qi2|  PDB=3qi2  |  SCENE=  }}


Authors: Bosch, D.E., Willard, F.S., Kimple, A.J., Miley, M.J., Siderovski, D.P.
===A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco===


Description: A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco
 
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{{ABSTRACT_PUBMED_22383884}}
 
==About this Structure==
[[3qi2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QI2 OCA].
 
==Reference==
<ref group="xtra">PMID:022383884</ref><ref group="xtra">PMID:017603074</ref><ref group="xtra">PMID:011976690</ref><references group="xtra"/>
[[Category: Heterotrimeric G-protein GTPase]]
[[Category: Homo sapiens]]
[[Category: Bosch, D E.]]
[[Category: Kimple, A J.]]
[[Category: Miley, M J.]]
[[Category: Siderovski, D P.]]
[[Category: Willard, F S.]]
[[Category: Adp-ribosylation]]
[[Category: All-helical domain]]
[[Category: Arginine finger]]
[[Category: Goloco motif]]
[[Category: Gtp binding]]
[[Category: Guanine nucleotide dissociation inhibitor]]
[[Category: Lipoprotein]]
[[Category: Nucleotide binding]]
[[Category: Ras-like domain]]
[[Category: Rgs14 goloco]]
[[Category: Signaling protein]]
[[Category: Transducer]]

Revision as of 05:48, 14 March 2012

File:3qi2.png

Template:STRUCTURE 3qi2

A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco

Template:ABSTRACT PUBMED 22383884

About this Structure

3qi2 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Bosch DE, Willard FS, Ramanujam R, Kimple AJ, Willard MD, Naqvi NI, Siderovski DP. A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis. PLoS Pathog. 2012 Feb;8(2):e1002553. Epub 2012 Feb 23. PMID:22383884 doi:10.1371/journal.ppat.1002553
  2. Sammond DW, Eletr ZM, Purbeck C, Kimple RJ, Siderovski DP, Kuhlman B. Structure-based protocol for identifying mutations that enhance protein-protein binding affinities. J Mol Biol. 2007 Aug 31;371(5):1392-404. Epub 2007 Jun 8. PMID:17603074 doi:10.1016/j.jmb.2007.05.096
  3. Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP. Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits. Nature. 2002 Apr 25;416(6883):878-81. PMID:11976690 doi:https://dx.doi.org/10.1038/416878a

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