1vsa: Difference between revisions

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==Overview==

Our understanding of the mechanism of protein synthesis has undergone, rapid progress in recent years as a result of low-resolution X-ray and, cryo-EM structures of ribosome functional complexes and high-resolution, structures of ribosomal subunits and vacant ribosomes. Here, we present, the crystal structure of the Thermus thermophilus 70S ribosome containing, a model mRNA and two tRNAs at 3.7 A resolution. Many structural details of, the interactions between the ribosome, tRNA, and mRNA in the P and E sites, and the ways in which tRNA structure is distorted by its interactions with, the ribosome are seen. Differences between the conformations of vacant and, tRNA-bound 70S ribosomes suggest an induced fit of the ribosome structure, in response to tRNA binding, including significant changes in the, peptidyl-transferase catalytic site.

Our understanding of the mechanism of protein synthesis has undergone rapid progress in recent years as a result of low-resolution X-ray and cryo-EM structures of ribosome functional complexes and high-resolution structures of ribosomal subunits and vacant ribosomes. Here, we present the crystal structure of the Thermus thermophilus 70S ribosome containing a model mRNA and two tRNAs at 3.7 A resolution. Many structural details of the interactions between the ribosome, tRNA, and mRNA in the P and E sites and the ways in which tRNA structure is distorted by its interactions with the ribosome are seen. Differences between the conformations of vacant and tRNA-bound 70S ribosomes suggest an induced fit of the ribosome structure in response to tRNA binding, including significant changes in the peptidyl-transferase catalytic site.

==About this Structure==

1VSA is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. This structure ~~superseeds~~ the now removed PDB entry 1VS9. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VSA OCA].

1VSA is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. This structure supersedes the now removed PDB entry 1VS9. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VSA OCA].

==Reference==

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[[Category: Korostelev, A.]]

[[Category: Laurberg, M.]]

[[Category: Noller, H.F.]]

[[Category: Noller, H F.]]

[[Category: Trakhanov, S.]]

[[Category: crystal structure]]

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[[Category: trna]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-Our understanding of the mechanism of protein synthesis has undergone, rapid progress in recent years as a result of low-resolution X-ray and, cryo-EM structures of ribosome functional complexes and high-resolution, structures of ribosomal subunits and vacant ribosomes. Here, we present, the crystal structure of the Thermus thermophilus 70S ribosome containing, a model mRNA and two tRNAs at 3.7 A resolution. Many structural details of, the interactions between the ribosome, tRNA, and mRNA in the P and E sites, and the ways in which tRNA structure is distorted by its interactions with, the ribosome are seen. Differences between the conformations of vacant and, tRNA-bound 70S ribosomes suggest an induced fit of the ribosome structure, in response to tRNA binding, including significant changes in the, peptidyl-transferase catalytic site.
+Our understanding of the mechanism of protein synthesis has undergone rapid progress in recent years as a result of low-resolution X-ray and cryo-EM structures of ribosome functional complexes and high-resolution structures of ribosomal subunits and vacant ribosomes. Here, we present the crystal structure of the Thermus thermophilus 70S ribosome containing a model mRNA and two tRNAs at 3.7 A resolution. Many structural details of the interactions between the ribosome, tRNA, and mRNA in the P and E sites and the ways in which tRNA structure is distorted by its interactions with the ribosome are seen. Differences between the conformations of vacant and tRNA-bound 70S ribosomes suggest an induced fit of the ribosome structure in response to tRNA binding, including significant changes in the peptidyl-transferase catalytic site.
 ==About this Structure==
-VSA is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. This structure superseeds the now removed PDB entry 1VS9. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VSA OCA].
+VSA is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. This structure supersedes the now removed PDB entry 1VS9. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VSA OCA].
 ==Reference==
@@ Line 15: / Line 15: @@
 [[Category: Korostelev, A.]]
 [[Category: Laurberg, M.]]
-[[Category: Noller, H.F.]]
+[[Category: Noller, H F.]]
 [[Category: Trakhanov, S.]]
 [[Category: crystal structure]]
@@ Line 25: / Line 25: @@
 [[Category: trna]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:15:32 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:38:08 2008''