Factor Xa: Difference between revisions
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The <scene name='Factor_Xa/Transparent_-_no_inhib_-_s2/3'>S2 site</scene> of factor Xa is formed by the 90s loop which is positioned adjacent to His57. Consistent with glycine as the P2 element in prothrombin, S2 is a small, shallow pocket.<ref name="Inhib">PMID: 11172669</ref> | The <scene name='Factor_Xa/Transparent_-_no_inhib_-_s2/3'>S2 site</scene> of factor Xa is formed by the 90s loop which is positioned adjacent to His57. Consistent with glycine as the P2 element in prothrombin, S2 is a small, shallow pocket.<ref name="Inhib">PMID: 11172669</ref> | ||
<scene name='Factor_Xa/Transparent_-_no_inhib_s4/2'>S4 pocket</scene> is formed between the 90s and 170s loops and binds an Ile. This region contains 3 ligand binding domains. The <scene name='Factor_Xa/Transparent_-_no_inhib_phob_bo/4'>hydrophobic box</scene> is located at the entrance to S4 and contains Phe174, Tyr99 and Trp215, which form a deep aryl-binding pocket. The <scene name='Factor_Xa/Transparent_-_no_inhib_oxianio/3'>cationic hole</scene> is formed by the backbone carbonyl and side chain of Glu97 and the backbone carbonyl of Lys96. The <scene name='Factor_Xa/Transparent_-_no_inhib-_h2o_si/3'>water site</scene> is composed of the | <scene name='Factor_Xa/Transparent_-_no_inhib_s4/2'>S4 pocket</scene> is formed between the 90s and 170s loops and binds an Ile. This region contains 3 ligand binding domains. The <scene name='Factor_Xa/Transparent_-_no_inhib_phob_bo/4'>hydrophobic box</scene> is located at the entrance to S4 and contains Phe174, Tyr99 and Trp215, which form a deep aryl-binding pocket. The <scene name='Factor_Xa/Transparent_-_no_inhib_oxianio/3'>cationic hole</scene> is formed by the backbone carbonyl and side chain of Glu97 and the backbone carbonyl of Lys96. The <scene name='Factor_Xa/Transparent_-_no_inhib-_h2o_si/3'>water site</scene> is composed of the hydrophillic side chains of Thr98, Ile175 and Thr177 and traps a water molecule. <ref name="Inhib" /> | ||
====Catalytic Triad==== | ====Catalytic Triad==== | ||
