2p74: Difference between revisions

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caption="2p74, resolution 0.88Å" />

'''CTX-M-9 class A beta-lactamase apo crystal structure at 0.88 Angstrom resolution'''<br />

~~==Overview==~~

The apo crystal structure of CTX-M-9 beta-lactamase has been determined to, 0.88 A at pH 8.8. This unusually clear picture of proton positions and, residue interactions supports the role of Glu166 as the general base for, the controversial acylation step of class A beta-lactamase catalysis. The, ability to distinguish low-energy conformations sampled by the enzyme, allows us to link the two conformations of Lys73 to different protonation, states of Glu166.

==About this Structure==

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==Reference==

The ~~Acylation Mechanism~~ of CTX-M beta-~~Lactamase~~ at 0.88 ~~A Resolution~~., Chen Y, Bonnet R, Shoichet BK, J Am Chem Soc. 2007 Apr 5;. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17408273 17408273]

The acylation mechanism of CTX-M beta-lactamase at 0.88 a resolution., Chen Y, Bonnet R, Shoichet BK, J Am Chem Soc. 2007 May 2;129(17):5378-80. Epub 2007 Apr 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17408273 17408273]

[[Category: Beta-lactamase]]

[[Category: Escherichia coli]]

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[[Category: Bonnet, R.]]

[[Category: Chen, Y.]]

[[Category: Shoichet, B.K.]]

[[Category: Shoichet, B K.]]

[[Category: K]]

[[Category: PO4]]

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[[Category: ultra-high resolution]]

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@@ Line 2: / Line 2: @@
 caption="2p74, resolution 0.88&Aring;" />
 '''CTX-M-9 class A beta-lactamase apo crystal structure at 0.88 Angstrom resolution'''<br />
-==Overview==
-The apo crystal structure of CTX-M-9 beta-lactamase has been determined to, 0.88 A at pH 8.8. This unusually clear picture of proton positions and, residue interactions supports the role of Glu166 as the general base for, the controversial acylation step of class A beta-lactamase catalysis. The, ability to distinguish low-energy conformations sampled by the enzyme, allows us to link the two conformations of Lys73 to different protonation, states of Glu166.
 ==About this Structure==
@@ Line 10: / Line 7: @@
 ==Reference==
-The Acylation Mechanism of CTX-M beta-Lactamase at 0.88 A Resolution., Chen Y, Bonnet R, Shoichet BK, J Am Chem Soc. 2007 Apr 5;. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17408273 17408273]
+The acylation mechanism of CTX-M beta-lactamase at 0.88 a resolution., Chen Y, Bonnet R, Shoichet BK, J Am Chem Soc. 2007 May 2;129(17):5378-80. Epub 2007 Apr 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17408273 17408273]
 [[Category: Beta-lactamase]]
 [[Category: Escherichia coli]]
@@ Line 16: / Line 13: @@
 [[Category: Bonnet, R.]]
 [[Category: Chen, Y.]]
-[[Category: Shoichet, B.K.]]
+[[Category: Shoichet, B K.]]
 [[Category: K]]
 [[Category: PO4]]
@@ Line 25: / Line 22: @@
 [[Category: ultra-high resolution]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:19:55 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:26:40 2008''