2hhn: Difference between revisions
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==Overview== | ==Overview== | ||
The synthesis and structure-activity relationship of a series of | The synthesis and structure-activity relationship of a series of arylaminoethyl amide cathepsin S inhibitors are reported. Optimization of P3 and P2 groups to improve overall physicochemical properties resulted in significant improvements in oral bioavailability over early lead compounds. An X-ray structure of compound 37 bound to the active site of cathepsin S is also reported. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Clark, K.]] | [[Category: Clark, K.]] | ||
[[Category: Harris, J | [[Category: Harris, J L.]] | ||
[[Category: Hornsby, M.]] | [[Category: Hornsby, M.]] | ||
[[Category: Karenewsky, D | [[Category: Karenewsky, D S.]] | ||
[[Category: Kulathila, R.]] | [[Category: Kulathila, R.]] | ||
[[Category: Lesley, S | [[Category: Lesley, S A.]] | ||
[[Category: Spraggon, G.]] | [[Category: Spraggon, G.]] | ||
[[Category: Tully, D | [[Category: Tully, D C.]] | ||
[[Category: GNQ]] | [[Category: GNQ]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
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[[Category: protease]] | [[Category: protease]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:42:05 2008'' | ||
Revision as of 15:42, 21 February 2008
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Cathepsin S in complex with non covalent arylaminoethyl amide.
Overview
The synthesis and structure-activity relationship of a series of arylaminoethyl amide cathepsin S inhibitors are reported. Optimization of P3 and P2 groups to improve overall physicochemical properties resulted in significant improvements in oral bioavailability over early lead compounds. An X-ray structure of compound 37 bound to the active site of cathepsin S is also reported.
About this Structure
2HHN is a Single protein structure of sequence from Homo sapiens with SO4 and GNQ as ligands. Active as Cathepsin S, with EC number 3.4.22.27 Full crystallographic information is available from OCA.
Reference
Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers., Tully DC, Liu H, Chatterjee AK, Alper PB, Epple R, Williams JA, Roberts MJ, Woodmansee DH, Masick BT, Tumanut C, Li J, Spraggon G, Hornsby M, Chang J, Tuntland T, Hollenbeck T, Gordon P, Harris JL, Karanewsky DS, Bioorg Med Chem Lett. 2006 Oct 1;16(19):5112-7. Epub 2006 Jul 28. PMID:16876402
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