Glycogenin: Difference between revisions
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Glycogenin has been identified in two human isoforms. Glycogenin-1 is a 37kDa muscle isoform encoded for by the gene GYG1, whereas glycogenin-2 is the 66kDa liver isoform that is encoded by the gene GYG2 and expressed primarily in cardiac muscle <ref name="five"> PMID:20357282 </ref>. Mutations of the GYG1 gene results in a loss of the autoglycosylation capabilities of glycogenin for initiating glycogen synthesis in muscle, which leads to problems such as cardiac arrhythmia and muscle weakness due to depleted or abnormal storage of glycogen in heart and skeletal muscle <ref name="five" />. | Glycogenin has been identified in two human isoforms. Glycogenin-1 is a 37kDa muscle isoform encoded for by the gene GYG1, whereas glycogenin-2 is the 66kDa liver isoform that is encoded by the gene GYG2 and expressed primarily in cardiac muscle <ref name="five"> PMID:20357282 </ref>. Mutations of the GYG1 gene results in a loss of the autoglycosylation capabilities of glycogenin for initiating glycogen synthesis in muscle, which leads to problems such as cardiac arrhythmia and muscle weakness due to depleted or abnormal storage of glycogen in heart and skeletal muscle <ref name="five" />. | ||
==3D structures of glycogenin== | |||
[[3q4s]] - hGYG1 – human<BR /> | |||
[[1ll0]], [[1ll3]] – rGYG1 – rabbit<BR /> | |||
[[1zcu]], [[1zcv]], [[1zcy]] - rGYG1 (mutant) | |||
===Glycogenin complex with Mn ion and UDP=== | |||
[[3rmv]] – hGYG1 (mutant) + Mn + UDP<BR /> | |||
[[3rmw]] - hGYG1 (mutant) + Mn + UDP-glucose<br /> | |||
[[3qvb]] - hGYG1 + Mn + UDP<BR /> | |||
[[1zct]] – rGYG1 + Mn + UDP<BR /> | |||
[[1zdf]], [[1zdg]] - rGYG1 (mutant) + Mn + UDP-glucose<br /> | |||
[[1ll2]] - rGYG1 + Mn + UDP-glucose<br /> | |||
==Additional Resources== | ==Additional Resources== | ||
