Sandbox Reserved 200: Difference between revisions
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==Trimers== | ==Trimers== | ||
RNase A trimers are formed in the same way as the dimers, except there are now three monomeric subunits. There is both a major and minor trimer. The structure of the major trimer is not known, but the two trimers can be separated by both chromatography and gel electrophoresis. <ref name="liu01"/> The major trimer is more common than the minor trimer. | RNase A trimers are formed in the same way as the dimers, except there are now three monomeric subunits. There is both a major and minor trimer. The structure of the major trimer is not known, but the two trimers can be separated by both chromatography and gel electrophoresis. <ref name="liu01"/> The major trimer is more common than the minor trimer. | ||
<Structure load='1JS0' size='400' frame='true' align='left' caption='Minor Trimer of RNase A' scene='Sandbox_Reserved_200/Minor_trimer/ | <Structure load='1JS0' size='400' frame='true' align='left' caption='Minor Trimer of RNase A' scene='Sandbox_Reserved_200/Minor_trimer/12' /> | ||
The <scene name='Sandbox_Reserved_200/Minor_trimer/ | The <scene name='Sandbox_Reserved_200/Minor_trimer/12'>minor trimer</scene> forms a cyclic propeller like shape. It is 3D domain swapped at the C-terminus of the beta strand.<ref name="liu01"/> No domain swapping a the N-terminus has been seen. When the minor trimer dissociates, it forms a dimer and a monomer. The minor and major dimer are both formed, but the major dimer is much more common.<ref name="liu01"/> | ||
