Sandbox Reserved 199: Difference between revisions
From Proteopedia
Jump to navigationJump to search
| Line 34: | Line 34: | ||
In 1957, Martin Saunder et al examined the structure of bovine pancreatic Ribonuclease using 1-Dimensional 1H NMR. | In 1957, Martin Saunder et al examined the structure of bovine pancreatic Ribonuclease using 1-Dimensional 1H NMR. | ||
In 1988, Udgaonkar et al. used 2-dimensional 1H NMR to study bovine pancreatic Ribonuclease and measured protein folding dynamics, which supported the framework model protein folding mechanism. | In 1988, Udgaonkar et al. used 2-dimensional 1H NMR to study bovine pancreatic Ribonuclease and measured protein folding dynamics, which supported the framework model protein folding mechanism.<ref name="Udgaonkar"/> | ||
In 1993, Santoro et al. used 3-dimensional 1H NMR to study bovine pancreatic Ribonuclease to compare NMR structures with X-Ray Crystallography structures of RNase A. | In 1993, Santoro et al. used 3-dimensional 1H NMR to study bovine pancreatic Ribonuclease to compare NMR structures with X-Ray Crystallography structures of RNase A.<ref name="Udgaonkar"/> | ||
In 2008, Rico et al. used 3-dimensional 1H NMR to study human pancreatic Ribonuclease. They looked at active site conformational changes upon substrate binding, and suggested possible biological implications. | In 2008, Rico et al. used 3-dimensional 1H NMR to study human pancreatic Ribonuclease. They looked at active site conformational changes upon substrate binding, and suggested possible biological implications.<ref name="Udgaonkar"/> | ||
===Medical Significance=== | ===Medical Significance=== | ||
