Factor Xa: Difference between revisions
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==Post-Translational Modifications== | ==Post-Translational Modifications== | ||
Factor X is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway)to release the activation peptide, and yield the active factor Xa. Zymogen human factor X has four carbohydrate-attachment sites | Factor X is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway)to release the activation peptide, and yield the active factor Xa. The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium via the GLA domain. Zymogen human factor X has four carbohydrate-attachment sites in the activation peptide, O-glycosidic linkages are to Thr17 and Thr29, and N-glycosidic linkages are to Asn39 and Asn49. | ||
==Enzyme Mechanism== | ==Enzyme Mechanism== | ||
