Factor Xa: Difference between revisions
From Proteopedia
Jump to navigationJump to search
| Line 43: | Line 43: | ||
===Activation peptide=== | ===Activation peptide=== | ||
Chymotrypsin-like proteases are synthesized as inactive precursors | Chymotrypsin-like proteases are synthesized as inactive precursors, zymogens, containing N-terminal extensions. Four segments are deformed in the zymogens of chymotrypsin and trypsin: the N-terminus to residue 19, residues 142-152, 184-193, and 216- 223 (these regions are collectively termed the activation domain). This region covers the S1 site and oxyanion hole, which explains the low activity of the zymogen. Proteolytic processing activates the zymogen, releasing the N-terminal Ile16. The new N-terminus forms a buried salt bridge with Asp194, inducing a conformational change that orders the activation domain. The S1 site and oxyanion hole are formed, creating the active protease. | ||
==Post-Translational Modifications== | ==Post-Translational Modifications== | ||
