3qtf: Difference between revisions

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[[Image:3qtf.png|left|200px]]
[[Image:3qtf.png|left|200px]]


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{{STRUCTURE_3qtf|  PDB=3qtf  |  SCENE=  }}  
{{STRUCTURE_3qtf|  PDB=3qtf  |  SCENE=  }}  


===Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity===
===Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity===


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{{ABSTRACT_PUBMED_21420297}}
{{ABSTRACT_PUBMED_21420297}}


==About this Structure==
==About this Structure==
[[3qtf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QTF OCA].  
[[3qtf]] is a 1 chain structure of [[Heat Shock Proteins]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QTF OCA].  
 
==See Also==
*[[Heat Shock Proteins|Heat Shock Proteins]]


==Reference==
==Reference==
<ref group="xtra">PMID:21420297</ref><references group="xtra"/>
<ref group="xtra">PMID:021420297</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bloom, J D.]]
[[Category: Bloom, J D.]]
Line 39: Line 31:
[[Category: Vogan, E M.]]
[[Category: Vogan, E M.]]
[[Category: Zapf, C W.]]
[[Category: Zapf, C W.]]
[[Category: Atp binding domain]]
[[Category: Atp-binding]]
[[Category: Chaperone]]
[[Category: Chaperone-chaperone inhibitor complex]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Stress response]]

Revision as of 02:32, 27 July 2012

File:3qtf.png

Template:STRUCTURE 3qtf

Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity

Template:ABSTRACT PUBMED 21420297

About this Structure

3qtf is a 1 chain structure of Heat Shock Proteins with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Zapf CW, Bloom JD, McBean JL, Dushin RG, Nittoli T, Ingalls C, Sutherland AG, Sonye JP, Eid CN, Golas J, Liu H, Boschelli F, Hu Y, Vogan E, Levin JI. Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2278-82. Epub 2011 Feb 28. PMID:21420297 doi:10.1016/j.bmcl.2011.02.101

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