3qgi: Difference between revisions

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[[Image:3qgi.jpg|left|200px]]
[[Image:3qgi.png|left|200px]]


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{{STRUCTURE_3qgi|  PDB=3qgi  |  SCENE=  }}  
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===Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase genotype 1a complex with N-[(2S)-butan-2-yl]-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide===
===Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase genotype 1a complex with N-[(2S)-butan-2-yl]-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide===


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{{ABSTRACT_PUBMED_21441029}}
{{ABSTRACT_PUBMED_21441029}}


==About this Structure==
==About this Structure==
[[3qgi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1a Hepatitis c virus subtype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QGI OCA].  
[[3qgi]] is a 1 chain structure of [[RNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1a Hepatitis c virus subtype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QGI OCA].  
 
==See Also==
*[[RNA polymerase|RNA polymerase]]


==Reference==
==Reference==
<ref group="xtra">PMID:21441029</ref><references group="xtra"/>
<ref group="xtra">PMID:021441029</ref><references group="xtra"/>
[[Category: Hepatitis c virus subtype 1a]]
[[Category: Hepatitis c virus subtype 1a]]
[[Category: RNA-directed RNA polymerase]]
[[Category: RNA-directed RNA polymerase]]
[[Category: Sheriff, S.]]
[[Category: Sheriff, S.]]
[[Category: Finger]]
[[Category: Hcv]]
[[Category: Ns5b]]
[[Category: Palm]]
[[Category: Polymerase]]
[[Category: Thumb]]
[[Category: Transferase-transferase inhibitor complex]]

Revision as of 21:12, 26 July 2012

File:3qgi.png

Template:STRUCTURE 3qgi

Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase genotype 1a complex with N-[(2S)-butan-2-yl]-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide

Template:ABSTRACT PUBMED 21441029

About this Structure

3qgi is a 1 chain structure of RNA polymerase with sequence from Hepatitis c virus subtype 1a. Full crystallographic information is available from OCA.

See Also

Reference

  1. Gentles RG, Sheriff S, Beno BR, Wan C, Kish K, Ding M, Zheng X, Chupak L, Poss MA, Witmer MR, Morin P, Wang YK, Rigat K, Lemm J, Voss S, Liu M, Pelosi L, Roberts SB, Gao M, Kadow JF. Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2212-5. Epub 2011 Mar 6. PMID:21441029 doi:10.1016/j.bmcl.2011.03.011

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