2ggb: Difference between revisions

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==Overview==

In this article we describe the application of structural biology methods, to the discovery of novel potent inhibitors of methionine aminopeptidases., These enzymes are employed by the cells to cleave the N-terminal, methionine from nascent peptides and proteins. As this is one of the, critical steps in protein maturation, it is very likely that inhibitors of, these enzymes may prove useful as novel antibacterial agents. Involvement, of crystallography at the very early stages of the inhibitor design, process resulted in serendipitous discovery of a new inhibitor class, the, pyrazole-diamines. Atomic-resolution structures of several inhibitors, bound to the enzyme illuminate a new mode of inhibitor binding.

In this article we describe the application of structural biology methods to the discovery of novel potent inhibitors of methionine aminopeptidases. These enzymes are employed by the cells to cleave the N-terminal methionine from nascent peptides and proteins. As this is one of the critical steps in protein maturation, it is very likely that inhibitors of these enzymes may prove useful as novel antibacterial agents. Involvement of crystallography at the very early stages of the inhibitor design process resulted in serendipitous discovery of a new inhibitor class, the pyrazole-diamines. Atomic-resolution structures of several inhibitors bound to the enzyme illuminate a new mode of inhibitor binding.

==About this Structure==

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[[Category: Methionyl aminopeptidase]]

[[Category: Single protein]]

[[Category: Evdokimov, A.G.]]

[[Category: Evdokimov, A G.]]

[[Category: Mekel, M.]]

[[Category: Pokross, M.E.]]

[[Category: Pokross, M E.]]

[[Category: Walter, R.L.]]

[[Category: Walter, R L.]]

[[Category: CO]]

[[Category: NA]]

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[[Category: pita-bread fold]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jan 23 15~~:30:26 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:31:22 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-In this article we describe the application of structural biology methods, to the discovery of novel potent inhibitors of methionine aminopeptidases., These enzymes are employed by the cells to cleave the N-terminal, methionine from nascent peptides and proteins. As this is one of the, critical steps in protein maturation, it is very likely that inhibitors of, these enzymes may prove useful as novel antibacterial agents. Involvement, of crystallography at the very early stages of the inhibitor design, process resulted in serendipitous discovery of a new inhibitor class, the, pyrazole-diamines. Atomic-resolution structures of several inhibitors, bound to the enzyme illuminate a new mode of inhibitor binding.
+In this article we describe the application of structural biology methods to the discovery of novel potent inhibitors of methionine aminopeptidases. These enzymes are employed by the cells to cleave the N-terminal methionine from nascent peptides and proteins. As this is one of the critical steps in protein maturation, it is very likely that inhibitors of these enzymes may prove useful as novel antibacterial agents. Involvement of crystallography at the very early stages of the inhibitor design process resulted in serendipitous discovery of a new inhibitor class, the pyrazole-diamines. Atomic-resolution structures of several inhibitors bound to the enzyme illuminate a new mode of inhibitor binding.
 ==About this Structure==
@@ Line 14: / Line 14: @@
 [[Category: Methionyl aminopeptidase]]
 [[Category: Single protein]]
-[[Category: Evdokimov, A.G.]]
+[[Category: Evdokimov, A G.]]
 [[Category: Mekel, M.]]
-[[Category: Pokross, M.E.]]
+[[Category: Pokross, M E.]]
-[[Category: Walter, R.L.]]
+[[Category: Walter, R L.]]
 [[Category: CO]]
 [[Category: NA]]
@@ Line 26: / Line 26: @@
 [[Category: pita-bread fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:30:26 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:31:22 2008''