Sandbox11: Difference between revisions
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==Binding== | ==Binding== | ||
By Andy Kim== | By Andy Kim== | ||
The active site of Torpedo californica acetylcholinesterase (TcAChE) is buried at the bottom of a narrow, deep gorge in the enzyme, and contains a catalytic triad consisting of Ser200, Glu327, and His440. When complexed with tacrine (THA), the aromatic rings of Trp84 and Phe330 sandwich the THA’s acridine ring . The phenyl ring of Phe330 lies parallel to and in contact with THA. THA is stacked against Trp-84. Its ring nitrogen is H-bonded to the main chain carbonyl oxygen of Hist-440 and it’s amino nitrogen is H-bonded to a water molecule. | |||
==Additional Features== | ==Additional Features== | ||
