Sandbox11: Difference between revisions
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==Introduction== | ==Introduction== | ||
Acetylcholinesterase breaks down acetylcholine into acetic acid and choline via a hydrolysis reaction. Acetylcholine is a neurotransmitter that signals muscle contraction. If acetylcholine is not broken down, then the chemical builds up in the synapses between nerve cells and muscle cells resulting in loss of muscle function and ultimately paralysis. The enzyme’s extremely fast reaction rate (approaching the diffusion limit) for breaking one acetylcholine into its two components indicates acetylcholinesterase’s biological importance. Many natural poisons and toxins work by inhibiting this enzyme, thus, paralyzing the victim. | Acetylcholinesterase breaks down acetylcholine into acetic acid and choline via a hydrolysis reaction. Acetylcholine is a neurotransmitter that signals muscle contraction. If acetylcholine is not broken down, then the chemical builds up in the synapses between nerve cells and muscle cells resulting in loss of muscle function and ultimately paralysis. The enzyme’s extremely fast reaction rate (approaching the diffusion limit) for breaking one acetylcholine into its two components indicates acetylcholinesterase’s biological importance. Many natural poisons and toxins work by inhibiting this enzyme, thus, paralyzing the victim. | ||
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==Overall structure== | ==Overall structure== | ||
{{STRUCTURE_1ea5 | PDB=1ea5 | SCENE= }} | {{STRUCTURE_1ea5 | PDB=1ea5 | SCENE= }} | ||
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==Binding== | ==Binding== | ||
{{STRUCTURE_1acj | PDB=1acj | SCENE= }} | {{STRUCTURE_1acj | PDB=1acj | SCENE= }} | ||
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==Additional Features== | ==Additional Features== | ||
==References== | ==References== | ||
(1) Perrier, AL; Massoulié J.; Krejci E. PRiMA: the membrane anchor of acetylcholinesterase in the brain. http://www.ncbi.nlm.nih.gov/pubmed/11804574. | (1) Perrier, AL; Massoulié J.; Krejci E. PRiMA: the membrane anchor of acetylcholinesterase in the brain. http://www.ncbi.nlm.nih.gov/pubmed/11804574. | ||
==Credits== | |||
Andy Kim | Introduction - Tyler Vlass | ||
Overall Structure - Zach Brentzel | |||
Drug Binding Site - Andy Kim | |||
Additional Features - Zach Hitzig | |||
