Sandbox11: Difference between revisions

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The active site of Torpedo californica acetylcholinesterase (TcAChE) is buried at the bottom of a narrow, deep gorge in the enzyme, and contains a catalytic triad (green scene) consisting of Ser200, Glu327, and His440. When complexed with tacrine (THA), the aromatic rings of Trp84 and Phe330 (green scene) sandwich the THA’s acridine ring . The phenyl ring of Phe330 lies parallel to and in contact with THA. THA is stacked against Trp-84. Its ring nitrogen is H-bonded to the main chain carbonyl oxygen of Hist-440 and it’s amino nitrogen is H-bonded to a water molecule.
The active site of Torpedo californica acetylcholinesterase (TcAChE) is buried at the bottom of a narrow, deep gorge in the enzyme, and contains a <scene name='Sandbox11/Catalytic_triad/6'>catalytic triad</scene> consisting of Ser200, Glu327, and His440. When complexed with tacrine (THA), the aromatic rings of Trp84 and Phe330 (green scene) sandwich the THA’s acridine ring . The phenyl ring of Phe330 lies parallel to and in contact with THA. THA is stacked against Trp-84. Its ring nitrogen is H-bonded to the main chain carbonyl oxygen of Hist-440 and it’s amino nitrogen is H-bonded to a water molecule.


==Additional Features==
==Additional Features==
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