TolA: Difference between revisions
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Although the exact function of TolA is not yet known, it has been shown that unlike mutations in the proteins of the TonB system to which the TolQRA proteins show many similarities, mutations in the TolQRA proteins affect the outer membrane integrity. TolA could be involved structurally by bringing the inner and outer membranes together and forming a bridge or link between them.<ref name='Sharyn'>PMID: 8416897</ref> | Although the exact function of TolA is not yet known, it has been shown that unlike mutations in the proteins of the TonB system to which the TolQRA proteins show many similarities, mutations in the TolQRA proteins affect the outer membrane integrity. TolA could be involved structurally by bringing the inner and outer membranes together and forming a bridge or link between them.<ref name='Sharyn'>PMID: 8416897</ref> | ||
TolA plays an important role in the import mechanisms for the uptake of bacteriotoxins (see [[Colicin]]) and the DNA of filamentous bacteriophages<ref name='Deprez'>PMID: 15701516</ref>, and has also been shown to be involved in the bacterial sensitivity to these groups<ref>PMID: 7853390</ref>, in particular the alpha helix of domain II, the deletion of which causes increased cellular sensitivity to deoxycholate (a detergent)<ref name='Schendel">PMID: 9171417</ref> | TolA plays an important role in the import mechanisms for the uptake of bacteriotoxins (see [[Colicin]]) and the DNA of filamentous bacteriophages<ref name='Deprez'>PMID: 15701516</ref>, and has also been shown to be involved in the bacterial sensitivity to these groups<ref>PMID: 7853390</ref>, in particular the alpha helix of domain II, the deletion of which causes increased cellular sensitivity to deoxycholate (a detergent)<ref name='Schendel">PMID: 9171417</ref>. | ||
===TolA and Colicin Uptake=== | ===TolA and Colicin Uptake=== | ||
