TolA: Difference between revisions
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==Structure== | ==Structure== | ||
TolA is located in the inner membrane and comprises of three domains: the N-terminal domain I (TolAI), from residues 1-47 including a 20-residue hydrophobic membrane spanning region which anchors the protein to the cytoplasmic membrane<ref>PMID: 7853390</ref>; domain II (TolAII), from residues 48-301, which forms a rigid helix connecting the domains either side of it; and the C-terminal domain III (TolAIII) from residues 302-421, which may be involved in the function of TolA by interacting with the periplasmic or outer membrane proteins, due to the tethering to domain II.<ref name='Sharyn'>PMID: 8416897</ref> | TolA is located in the inner membrane and comprises of three domains: the N-terminal domain I (TolAI), from residues 1-47 including a 20-residue hydrophobic membrane spanning region which anchors the protein to the cytoplasmic membrane<ref>PMID: 7853390</ref>; domain II (TolAII), from residues 48-301, which forms a rigid helix connecting the domains either side of it; and the C-terminal domain III (TolAIII) from residues 302-421, which may be involved in the function of TolA by interacting with the periplasmic or outer membrane proteins, due to the tethering to domain II.<ref name='Sharyn'>PMID: 8416897</ref> | ||
===C-terminal Domain=== | |||
{{STRUCTURE_1s62 | PDB=1s62 | SCENE= }} | |||
The c-terminal domain of [[TolA]] is directly involved with the N-terminal of both [[Colicin]] and the phage minor coat gene 3 protein. <ref>PMID: 15701516</ref> | |||
==Function== | ==Function== | ||
