Tol: Difference between revisions

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==Function==

As of yet, the cellular role of the Tol protein is unclear. However, the system components ~~are thought to~~ be involved in the maintenance of the outer membrane as mutations of Tol proteins result in cells which leak the contents of the periplasm, as well as a hypersensitivity to some detergents, antibiotics and other agents.<ref>PMID: 8955385</ref>. ~~It is also thought to~~ play a role in anchoring the outer membrane to the peptidoglycan layer through the interactions that occur between TolB, Pal, Lpp and OmpA<ref name='Bouveret'>PMID 7744736</ref>, ~~as well as the~~ regulation of porin activity due to the interactions seen between TolB and TolA<ref>PMID: 9393690</ref>.

As of yet, the cellular role of the Tol protein is unclear. However, there are several proposals for the different functions it may carry out:

* the system components could be involved in the maintenance of the outer membrane as mutations of Tol proteins result in cells which leak the contents of the periplasm, as well as a hypersensitivity to some detergents, antibiotics and other agents.<ref>PMID: 8955385</ref>.

* it may play a role in anchoring the outer membrane to the peptidoglycan layer through the interactions that occur between TolB, Pal, Lpp and OmpA<ref name='Bouveret'>PMID 7744736</ref>,

* possible regulation of porin activity due to the interactions seen between TolB and TolA<ref>PMID: 9393690</ref>.

* the Tol-Pal system may have the ability to localise in the membrane to a site of cell constriction, taking part in invagination of the outer membrane during cell division<ref>PMID: 17233825</ref>

===Interaction of Tol with Colicins===

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@@ Line 17: / Line 17: @@
 ==Function==
-As of yet, the cellular role of the Tol protein is unclear.  However, the system components are thought to be involved in the maintenance of the outer membrane as mutations of Tol proteins result in cells which leak the contents of the periplasm, as well as a hypersensitivity to some detergents, antibiotics and other agents.<ref>PMID: 8955385</ref>.  It is also thought to play a role in anchoring the outer membrane to the peptidoglycan layer through the interactions that occur between TolB, Pal, Lpp and OmpA<ref name='Bouveret'>PMID 7744736</ref>, as well as the regulation of porin activity due to the interactions seen between TolB and TolA<ref>PMID: 9393690</ref>.
+As of yet, the cellular role of the Tol protein is unclear.  However, there are several proposals for the different functions it may carry out:
+* the system components could be involved in the maintenance of the outer membrane as mutations of Tol proteins result in cells which leak the contents of the periplasm, as well as a hypersensitivity to some detergents, antibiotics and other agents.<ref>PMID: 8955385</ref>.
+* it may play a role in anchoring the outer membrane to the peptidoglycan layer through the interactions that occur between TolB, Pal, Lpp and OmpA<ref name='Bouveret'>PMID 7744736</ref>,
+* possible regulation of porin activity due to the interactions seen between TolB and TolA<ref>PMID: 9393690</ref>.
+* the Tol-Pal system may have the ability to localise in the membrane to a site of cell constriction, taking part in invagination of the outer membrane during cell division<ref>PMID: 17233825</ref>
 ===Interaction of Tol with Colicins===