TolQ: Difference between revisions

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==Structure==

TolQ is a polytopic protein located in the inner (cytoplasmic) membrane, containing approximately 230 amino acids. There are three membrane spanning segments in TolQ with each segment containing an α-helix.<ref>PMID: 7853390</ref> TM1 is connected to TM2 via a large cytoplasmic loop, with the N-terminal ending in the periplasm. This topology is also found in [[ExbB]].

TolQ is a polytopic protein located in the inner (cytoplasmic) membrane, containing approximately 230 amino acids. There are three membrane spanning segments in TolQ with each segment containing an α-helix<ref>PMID: 7853390</ref>. TM1 is connected to TM2 via a large cytoplasmic loop, with the N-terminal ending in the periplasm. This topology is also found in [[ExbB]], which can be explained by the similar sequence shared by both proteins<ref name='Braun'>PMID: 15205446</ref>.

It has been shown that 4 to 6 TolQ molecules associate in the TolQRA complex, and that they form multimers which interact with the transmembrane helices (TMH) of TolQ, TolR and TolA.<ref> PMID: 21285349</ref> The multimers are formed by the three TMHs of TolQ, the last of which undergo a conformational change to form a hairpin, while the first TMH forms an intermolecular interaction.<ref name='Vianney'> PMID:8300535</ref>

It has been shown that 4 to 6 TolQ molecules associate in the TolQRA complex, and that they form multimers which interact with the transmembrane helices (TMH) of TolQ, TolR and TolA<ref> PMID: 21285349</ref>. The multimers are formed by the three TMHs of TolQ, the last of which undergo a conformational change to form a hairpin, while the first TMH forms an intermolecular interaction<ref name='Vianney'> PMID:8300535</ref>.

==Function==

TolQ plays an important role in the maintenance of the bacterial envelope integrity as well as the import of filamentous bacteriophage and group A colicins.<ref name='Vianney'> PMID:8300535</ref>

TolQ plays an important role in the maintenance of the bacterial envelope integrity as well as the import of filamentous bacteriophage and group A colicins<ref name='Vianney'> PMID:8300535</ref>.

Loss of TolQ function can be partially replaced by ExbB and vice versa - reduced activities of either of these proteins via a mutant form can be reversed by introducing double mutants<ref name='Braun'>PMID: 15205446</ref>.

== References==

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 ==Structure==
-TolQ is a polytopic protein located in the inner (cytoplasmic) membrane, containing approximately 230 amino acids.  There are three membrane spanning segments in TolQ with each segment containing an α-helix.<ref>PMID: 7853390</ref>  TM1 is connected to TM2 via a large cytoplasmic loop, with the N-terminal ending in the periplasm.  This topology is also found in [[ExbB]].
+TolQ is a polytopic protein located in the inner (cytoplasmic) membrane, containing approximately 230 amino acids.  There are three membrane spanning segments in TolQ with each segment containing an α-helix<ref>PMID: 7853390</ref>.  TM1 is connected to TM2 via a large cytoplasmic loop, with the N-terminal ending in the periplasm.  This topology is also found in [[ExbB]], which can be explained by the similar sequence shared by both proteins<ref name='Braun'>PMID: 15205446</ref>.
-It has been shown that 4 to 6 TolQ molecules associate in the TolQRA complex, and that they form multimers which interact with the transmembrane helices (TMH) of TolQ, TolR and TolA.<ref> PMID: 21285349</ref>  The multimers are formed by the three TMHs of TolQ, the last of which undergo a conformational change to form a hairpin, while the first TMH forms an intermolecular interaction.<ref name='Vianney'> PMID:8300535</ref>
+It has been shown that 4 to 6 TolQ molecules associate in the TolQRA complex, and that they form multimers which interact with the transmembrane helices (TMH) of TolQ, TolR and TolA<ref> PMID: 21285349</ref>.  The multimers are formed by the three TMHs of TolQ, the last of which undergo a conformational change to form a hairpin, while the first TMH forms an intermolecular interaction<ref name='Vianney'> PMID:8300535</ref>.
 ==Function==
-TolQ plays an important role in the maintenance of the bacterial envelope integrity as well as the import of filamentous bacteriophage and group A colicins.<ref name='Vianney'> PMID:8300535</ref>
+TolQ plays an important role in the maintenance of the bacterial envelope integrity as well as the import of filamentous bacteriophage and group A colicins<ref name='Vianney'> PMID:8300535</ref>.
+Loss of TolQ function can be partially replaced by ExbB and vice versa - reduced activities of either of these proteins via a mutant form can be reversed by introducing double mutants<ref name='Braun'>PMID: 15205446</ref>.
 == References==
 <references/>