ExbD: Difference between revisions
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==Function== | ==Function== | ||
{{STRUCTURE_2pfu | PDB=2pfu | SCENE= Periplasmic_Domain_of_ExbD/Periplasmicdomainexbd/1 }} | |||
Like TolR, ExbD is also involved in the uptake of colicins across the outer membrane of Escherichia coli, but unlike TolR which transports group A colicins, ExbD transports group B colicins. It is also involved in the transferring of vitamin B<sub>12</sub> and ferric siderophores using energy-coupled transport. | Like TolR, ExbD is also involved in the uptake of colicins across the outer membrane of Escherichia coli, but unlike TolR which transports group A colicins, ExbD transports group B colicins. It is also involved in the transferring of vitamin B<sub>12</sub> and ferric siderophores using energy-coupled transport. | ||
ExbD is present in cells only in a complex with [[ExbB]], where is affects the functioning of the TonB complex both in how it responds to the proton motive force as well as its affinity with either the cytoplasmic or outer membrane. <ref>PMID: 12193634</ref> It has also been shown that TolR can replace the function of an ExbD mutant just as [[TolQ]] can with ExbB, suggesting an evolutionary link between the two complexes. | ExbD is present in cells only in a complex with [[ExbB]], where is affects the functioning of the TonB complex both in how it responds to the proton motive force as well as its affinity with either the cytoplasmic or outer membrane. <ref>PMID: 12193634</ref> It has also been shown that TolR can replace the function of an ExbD mutant just as [[TolQ]] can with ExbB, suggesting an evolutionary link between the two complexes. | ||
== References== | == References== | ||
<references/> | <references/> | ||
