Sandbox89220: Difference between revisions

[[File:Skin ulcer due to leishmaniasis, hand of Central American adult 3MG0037 lores.jpg|right|thumb|250px|alt=L.Mexicana|[[Skin ulcer due to leishmaniasis, hand of Central American adult]] by [[CDC/Dr. D.S. Martin]].]] PMM2 is not only important in survival and development in humans, it’s found that there is another form of PMM2 that’s expressed in the protozoan parasite Leishmania Mexicana[http://en.wikipedia.org/wiki/Leishmania_mexicana]which is believed to contribute to the virulence of the protozoan and enable them to survive in human host<ref>George N. Phillips Jr et al., Structures of proteins of biomedical interest from the Center for Eukaryotic Structural Genomics[https://springerlink3.metapress.com/content/gx8137632617qj70/resource-secured/?target=fulltext.pdf&sid=5j2ji155pgdvcsaff1ho3m55&sh=www.springerlink.com]</ref>. Since leishmaniasis[http://en.wikipedia.org/wiki/Leishmaniasis] is prevalent world-wide, finding an inhibitor to get rid of its virulence in hosts is very promising when it’s shown that the PMM in this particular protozoan has a close proximity to the structure of PMMs in human beings. The PMM in Leishmania Maxicana has about the same function as that of PMMs in humans, it’s crucial in synthesizing the activated mannose block for glycoconjugates for the survival of the parasites in host. However, as mentioned by Kedzierski et al., 2006, despite the fact that the close resemblance of the PMM in Leishmania Maxicana to PMMs in human can be an exciting discovery to thrive the pharmaceutical field for the drugs to kill the parasites, it also poses problems when the drugs could not distinguish between humans’ PMMs from PMM in the parasites.