217d: Difference between revisions
New page: left|200px<br /><applet load="217d" size="350" color="white" frame="true" align="right" spinBox="true" caption="217d, resolution 1.700Å" /> '''CRYSTAL STRUCTURES ... |
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==Overview== | ==Overview== | ||
Two DNA-RNA chimers, complexed with DNA minor groove binding drugs, have | Two DNA-RNA chimers, complexed with DNA minor groove binding drugs, have been observed to adopt the B-form conformation for the first time. Thus, the RNA duplex may assume the B-DNA conformation when interacting with drugs, peptides or proteins. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: modified]] | [[Category: modified]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:21:03 2008'' | ||
Revision as of 14:21, 21 February 2008
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CRYSTAL STRUCTURES OF THE B-FORM DNA-RNA CHIMER (5'-D(*IP*)-R(*CP*)-D(*IP*)-R(*CP*)-D(*IP*CP*IP*C)-3') COMPLEXED WITH DISTAMYCIN
Overview
Two DNA-RNA chimers, complexed with DNA minor groove binding drugs, have been observed to adopt the B-form conformation for the first time. Thus, the RNA duplex may assume the B-DNA conformation when interacting with drugs, peptides or proteins.
About this Structure
217D is a Protein complex structure of sequences from [1] with DMY and MG as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structures of B-form DNA-RNA chimers complexed with distamycin., Chen X, Ramakrishnan B, Sundaralingam M, Nat Struct Biol. 1995 Sep;2(9):733-5. PMID:7552741
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