244d: Difference between revisions

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==Overview==

Repeat tracts of guanine bases found in DNA and RNA can form tetraplex, structures in the presence of a variety of monovalent cations. Evidence, suggests that guanine tetraplexes assume important functions within, chromosomal telomeres, immunoglobulin switch regions, and the human, immunodeficiency virus genome. The structure of a parallel-stranded, tetraplex formed by the hexanucleotide d(TG4T) and stabilized by sodium, cations was determined by x-ray crystallography to 1.2 angstroms, resolution. Sharply resolved sodium cations were found between and within, planes of hydrogen-bonded guanine quartets, and an ordered groove, hydration was observed. Distinct intra- and intermolecular stacking, arrangements were adopted by the guanine quartets. Thymine bases were, exclusively involved in making extensive lattice contacts.

Repeat tracts of guanine bases found in DNA and RNA can form tetraplex structures in the presence of a variety of monovalent cations. Evidence suggests that guanine tetraplexes assume important functions within chromosomal telomeres, immunoglobulin switch regions, and the human immunodeficiency virus genome. The structure of a parallel-stranded tetraplex formed by the hexanucleotide d(TG4T) and stabilized by sodium cations was determined by x-ray crystallography to 1.2 angstroms resolution. Sharply resolved sodium cations were found between and within planes of hydrogen-bonded guanine quartets, and an ordered groove hydration was observed. Distinct intra- and intermolecular stacking arrangements were adopted by the guanine quartets. Thymine bases were exclusively involved in making extensive lattice contacts.

==About this Structure==

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[[Category: Protein complex]]

[[Category: Laughlan, G.]]

[[Category: Lilley, D.M.J.]]

[[Category: Lilley, D M.J.]]

[[Category: Luisi, B.]]

[[Category: Moody, P.C.E.]]

[[Category: Moody, P C.E.]]

[[Category: Moore, M.H.]]

[[Category: Moore, M H.]]

[[Category: Murchie, A.I.H.]]

[[Category: Murchie, A I.H.]]

[[Category: Norman, D.G.]]

[[Category: Norman, D G.]]

[[Category: CA]]

[[Category: NA]]

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[[Category: unusual dna]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:21:38 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-Repeat tracts of guanine bases found in DNA and RNA can form tetraplex, structures in the presence of a variety of monovalent cations. Evidence, suggests that guanine tetraplexes assume important functions within, chromosomal telomeres, immunoglobulin switch regions, and the human, immunodeficiency virus genome. The structure of a parallel-stranded, tetraplex formed by the hexanucleotide d(TG4T) and stabilized by sodium, cations was determined by x-ray crystallography to 1.2 angstroms, resolution. Sharply resolved sodium cations were found between and within, planes of hydrogen-bonded guanine quartets, and an ordered groove, hydration was observed. Distinct intra- and intermolecular stacking, arrangements were adopted by the guanine quartets. Thymine bases were, exclusively involved in making extensive lattice contacts.
+Repeat tracts of guanine bases found in DNA and RNA can form tetraplex structures in the presence of a variety of monovalent cations. Evidence suggests that guanine tetraplexes assume important functions within chromosomal telomeres, immunoglobulin switch regions, and the human immunodeficiency virus genome. The structure of a parallel-stranded tetraplex formed by the hexanucleotide d(TG4T) and stabilized by sodium cations was determined by x-ray crystallography to 1.2 angstroms resolution. Sharply resolved sodium cations were found between and within planes of hydrogen-bonded guanine quartets, and an ordered groove hydration was observed. Distinct intra- and intermolecular stacking arrangements were adopted by the guanine quartets. Thymine bases were exclusively involved in making extensive lattice contacts.
 ==About this Structure==
@@ Line 13: / Line 13: @@
 [[Category: Protein complex]]
 [[Category: Laughlan, G.]]
-[[Category: Lilley, D.M.J.]]
+[[Category: Lilley, D M.J.]]
 [[Category: Luisi, B.]]
-[[Category: Moody, P.C.E.]]
+[[Category: Moody, P C.E.]]
-[[Category: Moore, M.H.]]
+[[Category: Moore, M H.]]
-[[Category: Murchie, A.I.H.]]
+[[Category: Murchie, A I.H.]]
-[[Category: Norman, D.G.]]
+[[Category: Norman, D G.]]
 [[Category: CA]]
 [[Category: NA]]
@@ Line 25: / Line 25: @@
 [[Category: unusual dna]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 17:48:49 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:21:38 2008''