264d: Difference between revisions
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New page: left|200px<br /><applet load="264d" size="350" color="white" frame="true" align="right" spinBox="true" caption="264d, resolution 2.440Å" /> '''THREE-DIMENSIONAL C... |
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==Overview== | ==Overview== | ||
The molecular structure of the DNA A-tract dodecamer d(CGCAAATTTGCG) | The molecular structure of the DNA A-tract dodecamer d(CGCAAATTTGCG) complexed with the drug Hoechst 33258 has been determined by X-ray diffraction analysis. The Hoechst molecule binds in the DNA minor groove covering the sequence AATTT of the central A-tract, with the piperazine group close to one of the GC regions. The drug molecule makes two three-centered hydrogen bonds from the nitrogen atoms of the benzimidazole rings to the N3 and O2 atoms of the DNA bases. Although a high propeller twist is observed in the A-tract, only one unsymmetrical three-centered hydrogen bond is present in the DNA major groove. The structure is compared with other minor-groove-binding drug complexes and the influence of these drugs on DNA A-tracts is discussed. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Aymami, J.]] | [[Category: Aymami, J.]] | ||
[[Category: Boom, J | [[Category: Boom, J H.Van.]] | ||
[[Category: Coll, M.]] | [[Category: Coll, M.]] | ||
[[Category: Eritja, R.]] | [[Category: Eritja, R.]] | ||
[[Category: Garcia-Saez, I.]] | [[Category: Garcia-Saez, I.]] | ||
[[Category: Marel, G | [[Category: Marel, G A.Van Der.]] | ||
[[Category: Rich, A.]] | [[Category: Rich, A.]] | ||
[[Category: Vega, M | [[Category: Vega, M C.]] | ||
[[Category: HT]] | [[Category: HT]] | ||
[[Category: b-dna]] | [[Category: b-dna]] | ||
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[[Category: double helix]] | [[Category: double helix]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:21:58 2008'' | ||
