2alv: Difference between revisions
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New page: left|200px<br /><applet load="2alv" size="350" color="white" frame="true" align="right" spinBox="true" caption="2alv, resolution 1.90Å" /> '''X-ray structural ana... |
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==Overview== | ==Overview== | ||
Design, synthesis, and biological evaluation of peptidomimetic severe | Design, synthesis, and biological evaluation of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease (SARS-3CLpro) inhibitors for severe acute respiratory syndrome coronavirus (SARS-CoV) are described. These inhibitors exhibited antiviral activity against SARS-CoV in infected cells in the micromolar range. An X-ray crystal structure of our lead inhibitor (4) bound to SARS-3CLpro provided important drug-design templates for the design of small-molecule inhibitors. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Human sars coronavirus]] | [[Category: Human sars coronavirus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Baker, S | [[Category: Baker, S C.]] | ||
[[Category: Fu, W.]] | [[Category: Fu, W.]] | ||
[[Category: Ghosh, A | [[Category: Ghosh, A K.]] | ||
[[Category: Harcourt, B | [[Category: Harcourt, B H.]] | ||
[[Category: Johnson, M | [[Category: Johnson, M E.]] | ||
[[Category: Mesecar, A | [[Category: Mesecar, A D.]] | ||
[[Category: Ratia, K.]] | [[Category: Ratia, K.]] | ||
[[Category: Rota, P | [[Category: Rota, P A.]] | ||
[[Category: Santarsiero, B | [[Category: Santarsiero, B D.]] | ||
[[Category: Xi, K.]] | [[Category: Xi, K.]] | ||
[[Category: CY6]] | [[Category: CY6]] | ||
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[[Category: sars]] | [[Category: sars]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:28:39 2008'' | ||
