2auc: Difference between revisions

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==Overview==

The causative agents of malaria have developed a sophisticated machinery, for entering multiple cell types in the human and insect hosts. In this, machinery, a critical interaction occurs between the unusual myosin motor, MyoA and the MyoA-tail Interacting Protein (MTIP). Here we present one, crystal structure that shows three different conformations of Plasmodium, MTIP, one of these in complex with the MyoA-tail, which reveal major, conformational changes in the C-terminal domain of MTIP upon binding the, MyoA-tail helix, thereby creating several hydrophobic pockets in MTIP that, are the recipients of key hydrophobic side chains of MyoA. Because we also, show that the MyoA helix is able to block parasite growth, this provides, avenues for designing antimalarials.

The causative agents of malaria have developed a sophisticated machinery for entering multiple cell types in the human and insect hosts. In this machinery, a critical interaction occurs between the unusual myosin motor MyoA and the MyoA-tail Interacting Protein (MTIP). Here we present one crystal structure that shows three different conformations of Plasmodium MTIP, one of these in complex with the MyoA-tail, which reveal major conformational changes in the C-terminal domain of MTIP upon binding the MyoA-tail helix, thereby creating several hydrophobic pockets in MTIP that are the recipients of key hydrophobic side chains of MyoA. Because we also show that the MyoA helix is able to block parasite growth, this provides avenues for designing antimalarials.

==About this Structure==

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[[Category: Protein complex]]

[[Category: Bosch, J.]]

[[Category: Hol, W.G.J.]]

[[Category: Hol, W G.J.]]

[[Category: SGPP, Structural.Genomics.of.Pathogenic.Protozoa.Consortium.]]

[[Category: SGPP, Structural Genomics of Pathogenic Protozoa Consortium.]]

[[Category: Turley, S.]]

[[Category: myoa]]

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[[Category: structural genomics of pathogenic protozoa consortium]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:31:05 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-The causative agents of malaria have developed a sophisticated machinery, for entering multiple cell types in the human and insect hosts. In this, machinery, a critical interaction occurs between the unusual myosin motor, MyoA and the MyoA-tail Interacting Protein (MTIP). Here we present one, crystal structure that shows three different conformations of Plasmodium, MTIP, one of these in complex with the MyoA-tail, which reveal major, conformational changes in the C-terminal domain of MTIP upon binding the, MyoA-tail helix, thereby creating several hydrophobic pockets in MTIP that, are the recipients of key hydrophobic side chains of MyoA. Because we also, show that the MyoA helix is able to block parasite growth, this provides, avenues for designing antimalarials.
+The causative agents of malaria have developed a sophisticated machinery for entering multiple cell types in the human and insect hosts. In this machinery, a critical interaction occurs between the unusual myosin motor MyoA and the MyoA-tail Interacting Protein (MTIP). Here we present one crystal structure that shows three different conformations of Plasmodium MTIP, one of these in complex with the MyoA-tail, which reveal major conformational changes in the C-terminal domain of MTIP upon binding the MyoA-tail helix, thereby creating several hydrophobic pockets in MTIP that are the recipients of key hydrophobic side chains of MyoA. Because we also show that the MyoA helix is able to block parasite growth, this provides avenues for designing antimalarials.
 ==About this Structure==
@@ Line 14: / Line 14: @@
 [[Category: Protein complex]]
 [[Category: Bosch, J.]]
-[[Category: Hol, W.G.J.]]
+[[Category: Hol, W G.J.]]
-[[Category: SGPP, Structural.Genomics.of.Pathogenic.Protozoa.Consortium.]]
+[[Category: SGPP, Structural Genomics of Pathogenic Protozoa Consortium.]]
 [[Category: Turley, S.]]
 [[Category: myoa]]
@@ Line 26: / Line 26: @@
 [[Category: structural genomics of pathogenic protozoa consortium]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 18:10:05 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:31:05 2008''