3qhs: Difference between revisions
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{{STRUCTURE_3qhs| PDB=3qhs | SCENE= }} | {{STRUCTURE_3qhs| PDB=3qhs | SCENE= }} | ||
===Crystal structure of full-length Hfq from Escherichia coli=== | ===Crystal structure of full-length Hfq from Escherichia coli=== | ||
{{ABSTRACT_PUBMED_21543856}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/HFQ_ECOLI HFQ_ECOLI]] RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Involved in the regulation of stress responses mediated by the sigma factors RpoS, sigma-E and sigma-32. Binds with high specificity to tRNAs. In vitro, stimulates synthesis of long tails by poly(A) polymerase I. Required for RNA phage Qbeta replication.<ref>PMID:805130</ref> <ref>PMID:10677490</ref> <ref>PMID:11222598</ref> <ref>PMID:17158661</ref> <ref>PMID:19909729</ref> Seems to play a role in persister cell formation; upon overexpression decreases persister cell formation while deletion increases persister formation.<ref>PMID:805130</ref> <ref>PMID:10677490</ref> <ref>PMID:11222598</ref> <ref>PMID:17158661</ref> <ref>PMID:19909729</ref> | |||
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:021543856</ref><references group="xtra"/> | <ref group="xtra">PMID:021543856</ref><references group="xtra"/><references/> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Beich-Frandsen, M.]] | [[Category: Beich-Frandsen, M.]] | ||
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[[Category: Sjoeblom, B.]] | [[Category: Sjoeblom, B.]] | ||
[[Category: Vecerek, B.]] | [[Category: Vecerek, B.]] | ||
[[Category: Pleiotropic regulator]] | |||
[[Category: Rna binding protein]] | |||
[[Category: Sm-like]] | |||