2b3e: Difference between revisions

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==Overview==

The crystal structure of the DNA minor groove biphenyl benzimidazole, diamidine ligand DB819 has been determined, bound to the DNA sequence, d(CGCGAATTCGCG)(2), at a resolution of 1.36 Angstrom. Conditions for, reliable in silico docking that reproduce the observed position of the, ligand in the minor groove have been determined.

The crystal structure of the DNA minor groove biphenyl benzimidazole diamidine ligand DB819 has been determined, bound to the DNA sequence d(CGCGAATTCGCG)(2), at a resolution of 1.36 Angstrom. Conditions for reliable in silico docking that reproduce the observed position of the ligand in the minor groove have been determined.

==About this Structure==

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Targeting the DNA minor groove with fused ring dicationic compounds: comparison of in silico screening and a high-resolution crystal structure., Campbell NH, Evans DA, Lee MP, Parkinson GN, Neidle S, Bioorg Med Chem Lett. 2006 Jan 1;16(1):15-9. Epub 2005 Nov 2. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16263285 16263285]

[[Category: Protein complex]]

[[Category: Campbell, N.H.]]

[[Category: Campbell, N H.]]

[[Category: Evans, D.A.]]

[[Category: Evans, D A.]]

[[Category: Lee, M.P.]]

[[Category: Lee, M P.]]

[[Category: Neidle, S.]]

[[Category: Parkinson, G.N.]]

[[Category: Parkinson, G N.]]

[[Category: DBN]]

[[Category: MG]]

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[[Category: nucleic acids]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-The crystal structure of the DNA minor groove biphenyl benzimidazole, diamidine ligand DB819 has been determined, bound to the DNA sequence, d(CGCGAATTCGCG)(2), at a resolution of 1.36 Angstrom. Conditions for, reliable in silico docking that reproduce the observed position of the, ligand in the minor groove have been determined.
+The crystal structure of the DNA minor groove biphenyl benzimidazole diamidine ligand DB819 has been determined, bound to the DNA sequence d(CGCGAATTCGCG)(2), at a resolution of 1.36 Angstrom. Conditions for reliable in silico docking that reproduce the observed position of the ligand in the minor groove have been determined.
 ==About this Structure==
@@ Line 12: / Line 12: @@
 Targeting the DNA minor groove with fused ring dicationic compounds: comparison of in silico screening and a high-resolution crystal structure., Campbell NH, Evans DA, Lee MP, Parkinson GN, Neidle S, Bioorg Med Chem Lett. 2006 Jan 1;16(1):15-9. Epub 2005 Nov 2. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16263285 16263285]
 [[Category: Protein complex]]
-[[Category: Campbell, N.H.]]
+[[Category: Campbell, N H.]]
-[[Category: Evans, D.A.]]
+[[Category: Evans, D A.]]
-[[Category: Lee, M.P.]]
+[[Category: Lee, M P.]]
 [[Category: Neidle, S.]]
-[[Category: Parkinson, G.N.]]
+[[Category: Parkinson, G N.]]
 [[Category: DBN]]
 [[Category: MG]]
@@ Line 35: / Line 35: @@
 [[Category: nucleic acids]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 18:15:35 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:33:42 2008''