3b4y: Difference between revisions

Line 1:

~~[[Image:3b4y.png|left|200px]]~~

~~<!--~~

~~The line below this paragraph, containing "STRUCTURE_3b4y", creates the "Structure Box" on the page.~~

~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~

~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~

~~or leave the SCENE parameter empty for the default display.~~

~~-->~~

===FGD1 (Rv0407) from Mycobacterium tuberculosis===

==Function==

~~<!--~~

[[http://www.uniprot.org/uniprot/P96253_MYCTU P96253_MYCTU]] Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone. Is essential for the bioreductive activation of the prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It does not interact directly with PA-824 but, rather, provides reduced F420 to an accessory protein (Rv3547), which in turn activates PA-824. Also probably has a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria.<ref>PMID:10879539</ref><ref>PMID:18434308</ref>

~~The line below this paragraph, {{ABSTRACT_PUBMED_18434308}}, adds the Publication Abstract to the page~~

~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~)~~, where 18434308 is the PubMed ID number~~.

-->

~~{{ABSTRACT_PUBMED_18434308}}~~

==About this Structure==

Line 22:

Line 10:

==Reference==

[[Category: Mycobacterium tuberculosis h37rv]]

[[Category: Baker, E N.]]

Line 29:

Line 17:

[[Category: Squire, C J.]]

[[Category: TBSGC, TB Structural Genomics Consortium.]]

[[Category: F420 binding]]

[[Category: Non-prolyl cis-peptide bulge]]

[[Category: Oxidoreductase]]

[[Category: Structural genomic]]

[[Category: Tb structural genomics consortium]]

[[Category: Tbsgc]]

[[Category: Tim-barrel]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:3b4y.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3b4y", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3b4y|  PDB=3b4y  |  SCENE=  }}
 ===FGD1 (Rv0407) from Mycobacterium tuberculosis===
+{{ABSTRACT_PUBMED_18434308}}
+==Function==
-<!--
+[[http://www.uniprot.org/uniprot/P96253_MYCTU P96253_MYCTU]] Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone. Is essential for the bioreductive activation of the prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It does not interact directly with PA-824 but, rather, provides reduced F420 to an accessory protein (Rv3547), which in turn activates PA-824. Also probably has a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria.<ref>PMID:10879539</ref><ref>PMID:18434308</ref>
-The line below this paragraph, {{ABSTRACT_PUBMED_18434308}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 18434308 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_18434308}}
 ==About this Structure==
@@ Line 22: / Line 10: @@
 ==Reference==
-<ref group="xtra">PMID:018434308</ref><references group="xtra"/>
+<ref group="xtra">PMID:018434308</ref><references group="xtra"/><references/>
 [[Category: Mycobacterium tuberculosis h37rv]]
 [[Category: Baker, E N.]]
@@ Line 29: / Line 17: @@
 [[Category: Squire, C J.]]
 [[Category: TBSGC, TB Structural Genomics Consortium.]]
+[[Category: F420 binding]]
+[[Category: Non-prolyl cis-peptide bulge]]
+[[Category: Oxidoreductase]]
+[[Category: Structural genomic]]
+[[Category: Tb structural genomics consortium]]
+[[Category: Tbsgc]]
+[[Category: Tim-barrel]]