User:Meng Han Liu/Sandbox 1: Difference between revisions

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==Introduction==
==Introduction==


In prokaryotes such as [http://en.wikipedia.org/wiki/E.coli ''E. coli'']  and [http://en.wikipedia.org/wiki/B._subtilis ''B. subtilis''], chromosomal DNA exists in a circular fashion whereby [[DNA Replication, Transcription and Translation#DNA replication|DNA replication]] takes place at a common [http://en.wikipedia.org/wiki/Origin_of_replication#Prokaryotic origin] (''oriC'') <ref>Duggin, I.G. and S.D. Bell, Termination Structures in the Escherichia coli Chromosome Replication Fork Trap. Journal of Molecular Biology, 2009. 387(3): p. 532-539</ref>. Two replication forks move bidirectionally from ''oriC'' to replicate DNA until they meet, and the forks fuse with one another to form two circular daughter chromosomes <ref>Wake, R.G. and G.F. King, A tale of two terminators: crystal structures sharpen the debate on DNA replication fork arrest mechanisms. Structure, 1997. 5: p. 1-5</ref>.
In prokaryotes such as [http://en.wikipedia.org/wiki/E.coli ''E. coli'']  and [http://en.wikipedia.org/wiki/B._subtilis ''B. subtilis''], chromosomal DNA exists in a circular fashion whereby [[DNA Replication, Transcription and Translation#DNA replication|DNA replication]] takes place at a common [http://en.wikipedia.org/wiki/Origin_of_replication#Prokaryotic origin] (''oriC'') <ref>Duggin, I.G. and S.D. Bell, Termination Structures in the Escherichia coli Chromosome Replication Fork Trap. Journal of Molecular Biology, 2009. 387(3): p. 532-539</ref>. Two [http://en.wikipedia.org/wiki/Replication_fork replication forks] move bidirectionally from ''oriC'' to replicate DNA until they meet, and the forks fuse with one another to form two circular daughter chromosomes <ref>Wake, R.G. and G.F. King, A tale of two terminators: crystal structures sharpen the debate on DNA replication fork arrest mechanisms. Structure, 1997. 5: p. 1-5</ref>. The region where the two replication forks meet is defined as the “terminus region”, located roughly opposite of ''oriC''<ref>Duggin, I.G., Wake, R. Gerry, Bell, Stephen D. Bell and Hill, Thomas M., The replication fork trap and termination of chromosome replication. Molecular Microbiology, 2008. 70(6): p. 1323-1333</ref>.




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