Sandbox20: Difference between revisions
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===DNA Binding=== | ===DNA Binding=== | ||
[[Image:Tus 2 DNA-binding domain.jpg | thumb | upright=1.4| | [[Image:Tus 2 DNA-binding domain.jpg | thumb | upright=1.4| right| Interaction between the beta sheet domain of Tus and the TerB DNA region.]] | ||
Tus is among the most stable monomeric, sequence-specific, double-stranded DNA-binding proteins. This is due to a combination of three major sets of interactions; base-specific polar interactions within the major groove, non-polar contacts with the carboxy domain, and a phosphate clamp within the amino domain. | Tus is among the most stable monomeric, sequence-specific, double-stranded DNA-binding proteins. This is due to a combination of three major sets of interactions; base-specific polar interactions within the major groove, non-polar contacts with the carboxy domain, and a phosphate clamp within the amino domain. | ||
