Sandbox20: Difference between revisions

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[[Image:Theta Model of Replication.jpg | thumb | upright=1.7| right| Schematic representation of the replication termination fork and fork traps of the E. coli and B. subtilis chromosomes.]]

The replication of chromosomal DNA in most bacterial species occurs through a bidirectional mechanism, whereby two replication forks derived from the same origin of replication travel in opposite directions.<ref>PMID: 4562743</ref> This gives rise to the characteristic theta-shaped structure as the nascent DNA loop connecting the replication forks is generated. While the use of two [[1b77| replisomes]], one at each fork, accelerates replication, the phase of termination must be carefully coordinated. Specific sequences known as ''Ter sites'' lie just beyond the halfway point for each replisome. These halt the advance of replication forks in a direction-specific manner, and thereby form a ''replication fork trap''. As a result, each replisome can traverse only slightly more than half of the DNA before it is arrested. Together, the two sets of Ter sites define the terminus region where replication is terminated and the two forks fuse.

The replication of chromosomal DNA in most bacterial species occurs through a bidirectional mechanism, whereby two replication forks derived from the same origin of replication travel in opposite directions.<ref>PMID: 4562743</ref> This gives rise to the characteristic theta-shaped structure while the nascent DNA loop connecting the replication forks is generated. While the use of two [[1b77| replisomes]], one at each fork, accelerates replication, the phase of termination must be carefully coordinated. Specific sequences known as ''Ter sites'' lie just beyond the halfway point for each replisome. These halt the advance of replication forks in a direction-specific manner, and thereby form a ''replication fork trap''. As a result, each replisome can traverse only slightly more than half of the DNA before it is arrested. Together, the two sets of Ter sites define the terminus region where replication is terminated and the two forks fuse.

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Revision as of 00:11, 22 May 2011 view source Michael Webster (talk \| contribs) 118 edits →Tus ← Older edit		Revision as of 02:28, 22 May 2011 view source Michael Webster (talk \| contribs) 118 edits m →Replication Termination in ''Escherichia coli'' and ''Bacillus subtilis'' Newer edit →
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	[[Image:Theta Model of Replication.jpg \| thumb \| upright=1.7\| right\| Schematic representation of the replication termination fork and fork traps of the E. coli and B. subtilis chromosomes.]]		[[Image:Theta Model of Replication.jpg \| thumb \| upright=1.7\| right\| Schematic representation of the replication termination fork and fork traps of the E. coli and B. subtilis chromosomes.]]

	The replication of chromosomal DNA in most bacterial species occurs through a bidirectional mechanism, whereby two replication forks derived from the same origin of replication travel in opposite directions.<ref>PMID: 4562743</ref> This gives rise to the characteristic theta-shaped structure as the nascent DNA loop connecting the replication forks is generated. While the use of two [[1b77\| replisomes]], one at each fork, accelerates replication, the phase of termination must be carefully coordinated. Specific sequences known as ''Ter sites'' lie just beyond the halfway point for each replisome. These halt the advance of replication forks in a direction-specific manner, and thereby form a ''replication fork trap''. As a result, each replisome can traverse only slightly more than half of the DNA before it is arrested. Together, the two sets of Ter sites define the terminus region where replication is terminated and the two forks fuse.		The replication of chromosomal DNA in most bacterial species occurs through a bidirectional mechanism, whereby two replication forks derived from the same origin of replication travel in opposite directions.<ref>PMID: 4562743</ref> This gives rise to the characteristic theta-shaped structure while the nascent DNA loop connecting the replication forks is generated. While the use of two [[1b77\| replisomes]], one at each fork, accelerates replication, the phase of termination must be carefully coordinated. Specific sequences known as ''Ter sites'' lie just beyond the halfway point for each replisome. These halt the advance of replication forks in a direction-specific manner, and thereby form a ''replication fork trap''. As a result, each replisome can traverse only slightly more than half of the DNA before it is arrested. Together, the two sets of Ter sites define the terminus region where replication is terminated and the two forks fuse.