RTP and Tus: Difference between revisions

Perhaps surprisingly, replication fork termination has also been identified in specific regions of eukaryotes chromosoms.  In the yeast ''Saccharomyces cerevisiae'' the terminator protein Fob1p has been shown to arrest the replication fork at ''Ter'' sites in non-transcribed spacer regions of rDNA; while in ''Schizosaccharomyes pombe'' polar replication termination by RTS1 has been shown to control the direction of replication of the ''mat1'' mating locus, enabling ''S. pombe'' to alternate between mating types. This provides evidence that the replication termination process has been adapted by a wide range of organisms and is able to perform a variety of functions, opening up an exciting new field of research. <ref>Kaplan DL, Bastia D (2009) Mechanisms of polar arrest of a replication fork. ''Molecular Microbiology'' 72(2): 279-285.</ref>.