RTP and Tus: Difference between revisions
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Looking at the structures of these two proteins, it is not immediately obvious that they would perfom the same function; to arrest the progression of the replication fork along the bacterial chromosome at specific sites (''Ter'' sites). Furthermore, this arrest-mechanism functions in a polar manner in both organisms, which is perhaps surprising considering the symmetrical characteristics of both proteins.<ref>Wake, RG and King, GF (1997) A tale of two terminators: crystal structures sharpen the debate on DNA replication fork arrest mechanisms. ''Structure'' 5: 1-5.</ref> | Looking at the structures of these two proteins, it is not immediately obvious that they would perfom the same function; to arrest the progression of the replication fork along the bacterial chromosome at specific sites (''Ter'' sites). Furthermore, this arrest-mechanism functions in a polar manner in both organisms, which is perhaps surprising considering the symmetrical characteristics of both proteins.<ref>Wake, RG and King, GF (1997) A tale of two terminators: crystal structures sharpen the debate on DNA replication fork arrest mechanisms. ''Structure'' 5: 1-5.</ref> | ||
[[Image:Replication_fork.jpg|300px|right|thumb| Schematic representation of ''Ter'' sites in ''B. subtilis'' and ''E. coli''. ]] | [[Image:Replication_fork.jpg|300px|right|thumb| Schematic representation of ''Ter'' sites in ''B. subtilis'' and ''E. coli'', Taken from Duggin ''et al'' (2008). ]] | ||
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[[Image:1BM9.2.jpg|400px|left|thumb| First determined RTP structure. By Bussiere ''et al.'' ( | [[Image:1BM9.2.jpg|400px|left|thumb| First determined RTP structure. By Bussiere ''et al.''(1995)]][[Image:1ECR.jpg|400px|right|thumb| Unlocked Tus-''Ter'' complex, detemined by Kamada ''et al.''(1996)]] | ||
