2bm4: Difference between revisions
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New page: left|200px<br /><applet load="2bm4" size="350" color="white" frame="true" align="right" spinBox="true" caption="2bm4, resolution 2.2Å" /> '''THE STRUCTURE OF MFPA... |
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==Overview== | ==Overview== | ||
Fluoroquinolones are gaining increasing importance in the treatment of | Fluoroquinolones are gaining increasing importance in the treatment of tuberculosis. The expression of MfpA, a member of the pentapeptide repeat family of proteins from Mycobacterium tuberculosis, causes resistance to ciprofloxacin and sparfloxacin. This protein binds to DNA gyrase and inhibits its activity. Its three-dimensional structure reveals a fold, which we have named the right-handed quadrilateral beta helix, that exhibits size, shape, and electrostatic similarity to B-form DNA. This represents a form of DNA mimicry and explains both its inhibitory effect on DNA gyrase and fluoroquinolone resistance resulting from the protein's expression in vivo. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Blanchard, J | [[Category: Blanchard, J S.]] | ||
[[Category: Hegde, S | [[Category: Hegde, S S.]] | ||
[[Category: Maxwell, A.]] | [[Category: Maxwell, A.]] | ||
[[Category: Mitchenall, L | [[Category: Mitchenall, L A.]] | ||
[[Category: Roderick, S | [[Category: Roderick, S L.]] | ||
[[Category: Takiff, H | [[Category: Takiff, H E.]] | ||
[[Category: Vetting, M | [[Category: Vetting, M W.]] | ||
[[Category: dna gyrase]] | [[Category: dna gyrase]] | ||
[[Category: dna mimicry]] | [[Category: dna mimicry]] | ||
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[[Category: right-handed quadrilateral beta-helix]] | [[Category: right-handed quadrilateral beta-helix]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:39:14 2008'' | ||
