3nma: Difference between revisions
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{{STRUCTURE_3nma| PDB=3nma | SCENE= }} | {{STRUCTURE_3nma| PDB=3nma | SCENE= }} | ||
===Mutant P169S of Foot-and-mouth disease Virus RNA dependent RNA-polymerase=== | ===Mutant P169S of Foot-and-mouth disease Virus RNA dependent RNA-polymerase=== | ||
{{ABSTRACT_PUBMED_20865120}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/Q9QCE4_9PICO Q9QCE4_9PICO]] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047] | |||
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020865120</ref><references group="xtra"/> | <ref group="xtra">PMID:020865120</ref><references group="xtra"/><references/> | ||
[[Category: Foot-and-mouth disease virus - type c]] | [[Category: Foot-and-mouth disease virus - type c]] | ||
[[Category: Agudo, R.]] | [[Category: Agudo, R.]] | ||
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[[Category: Perez-Luque, R.]] | [[Category: Perez-Luque, R.]] | ||
[[Category: Verdaguer, N.]] | [[Category: Verdaguer, N.]] | ||
[[Category: 3d polymerase rna-dependent rna polymerase]] | |||
[[Category: Foot-and-mouth disease virus]] | |||
[[Category: Picornavirus]] | |||
[[Category: Ribavirin]] | |||
[[Category: Transferase-rna complex]] | |||
Revision as of 11:43, 24 April 2013
Mutant P169S of Foot-and-mouth disease Virus RNA dependent RNA-polymerase
Template:ABSTRACT PUBMED 20865120
Function
[Q9QCE4_9PICO] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]
About this Structure
3nma is a 3 chain structure with sequence from Foot-and-mouth disease virus - type c. Full crystallographic information is available from OCA.
Reference
- Agudo R, Ferrer-Orta C, Arias A, de la Higuera I, Perales C, Perez-Luque R, Verdaguer N, Domingo E. A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape. PLoS Pathog. 2010 Aug 26;6(8). pii: e1001072. PMID:20865120 doi:10.1371/journal.ppat.1001072
