2cs7: Difference between revisions

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==Overview==

The recently described pneumococcal histidine triad protein family has, been shown to be highly conserved within the pneumococcus. As part of our, structural genomics effort on proteins from Streptococcus pneumoniae, we, have expressed, crystallised and solved the structure of PhtA-166-220 at, 1.2 Angstroms using remote SAD with zinc. The structure of PhtA-166-220, shows no similarity to any protein structure. The overall fold contains, 3beta-strands and a single short alpha-helix. The structure appears to, contain a novel zinc binding motif. The remaining 4 histidine triad, repeats from PhtA have been modelled based on the crystal structure of the, PhtA histidine triad repeat 2. From this modelling work, we speculate that, only three of the five histidine triad repeats contain the residues in the, correct geometry to allow the binding of a zinc ion.

The recently described pneumococcal histidine triad protein family has been shown to be highly conserved within the pneumococcus. As part of our structural genomics effort on proteins from Streptococcus pneumoniae, we have expressed, crystallised and solved the structure of PhtA-166-220 at 1.2 Angstroms using remote SAD with zinc. The structure of PhtA-166-220 shows no similarity to any protein structure. The overall fold contains 3beta-strands and a single short alpha-helix. The structure appears to contain a novel zinc binding motif. The remaining 4 histidine triad repeats from PhtA have been modelled based on the crystal structure of the PhtA histidine triad repeat 2. From this modelling work, we speculate that only three of the five histidine triad repeats contain the residues in the correct geometry to allow the binding of a zinc ion.

==About this Structure==

Line 13:

[[Category: Single protein]]

[[Category: Streptococcus pneumoniae]]

[[Category: Isaacs, N.W.]]

[[Category: Isaacs, N W.]]

[[Category: Mitchell, T.J.]]

[[Category: Mitchell, T J.]]

[[Category: Riboldi-Tunnicliffe, A.]]

[[Category: ZN]]

[[Category: phta]]

[[Category: pneumococcal histidine triad protein]]

[[Category: s.pneumoniae]]

[[Category: s pneumoniae]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-The recently described pneumococcal histidine triad protein family has, been shown to be highly conserved within the pneumococcus. As part of our, structural genomics effort on proteins from Streptococcus pneumoniae, we, have expressed, crystallised and solved the structure of PhtA-166-220 at, 1.2 Angstroms using remote SAD with zinc. The structure of PhtA-166-220, shows no similarity to any protein structure. The overall fold contains, 3beta-strands and a single short alpha-helix. The structure appears to, contain a novel zinc binding motif. The remaining 4 histidine triad, repeats from PhtA have been modelled based on the crystal structure of the, PhtA histidine triad repeat 2. From this modelling work, we speculate that, only three of the five histidine triad repeats contain the residues in the, correct geometry to allow the binding of a zinc ion.
+The recently described pneumococcal histidine triad protein family has been shown to be highly conserved within the pneumococcus. As part of our structural genomics effort on proteins from Streptococcus pneumoniae, we have expressed, crystallised and solved the structure of PhtA-166-220 at 1.2 Angstroms using remote SAD with zinc. The structure of PhtA-166-220 shows no similarity to any protein structure. The overall fold contains 3beta-strands and a single short alpha-helix. The structure appears to contain a novel zinc binding motif. The remaining 4 histidine triad repeats from PhtA have been modelled based on the crystal structure of the PhtA histidine triad repeat 2. From this modelling work, we speculate that only three of the five histidine triad repeats contain the residues in the correct geometry to allow the binding of a zinc ion.
 ==About this Structure==
@@ Line 13: / Line 13: @@
 [[Category: Single protein]]
 [[Category: Streptococcus pneumoniae]]
-[[Category: Isaacs, N.W.]]
+[[Category: Isaacs, N W.]]
-[[Category: Mitchell, T.J.]]
+[[Category: Mitchell, T J.]]
 [[Category: Riboldi-Tunnicliffe, A.]]
 [[Category: ZN]]
 [[Category: phta]]
 [[Category: pneumococcal histidine triad protein]]
-[[Category: s.pneumoniae]]
+[[Category: s pneumoniae]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 18:46:56 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:51:53 2008''