3ld1: Difference between revisions

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~~[[Image:3ld1.jpg|left|200px]]~~

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===Crystal Structure of IBV Nsp2a===

==Function==

[[http://www.uniprot.org/uniprot/R1A_IBVM R1A_IBVM]] The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc (By similarity). The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity). The peptide p16 might be involved in the EGF signaling pathway (By similarity). Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity). Nsp9 is a ssRNA-binding protein (By similarity).

==About this Structure==

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[[Category: Xu, Y.]]

[[Category: Yang, A.]]

[[Category: Globular like]]

[[Category: Host cytoplasm]]

[[Category: Host membrane]]

[[Category: Hydrolase]]

[[Category: Membrane]]

[[Category: Metal-binding]]

[[Category: Protease]]

[[Category: Rna-binding]]

[[Category: Thiol protease]]

[[Category: Transmembrane]]

[[Category: Zinc-finger]]

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-[[Image:3ld1.jpg|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3ld1", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3ld1|  PDB=3ld1  |  SCENE=  }}
 ===Crystal Structure of IBV Nsp2a===
+==Function==
+[[http://www.uniprot.org/uniprot/R1A_IBVM R1A_IBVM]] The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc (By similarity).  The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity).  The peptide p16 might be involved in the EGF signaling pathway (By similarity).  Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity).  Nsp9 is a ssRNA-binding protein (By similarity).
 ==About this Structure==
@@ Line 24: / Line 17: @@
 [[Category: Xu, Y.]]
 [[Category: Yang, A.]]
+[[Category: Globular like]]
+[[Category: Host cytoplasm]]
+[[Category: Host membrane]]
+[[Category: Hydrolase]]
+[[Category: Membrane]]
+[[Category: Metal-binding]]
+[[Category: Protease]]
+[[Category: Rna-binding]]
+[[Category: Thiol protease]]
+[[Category: Transmembrane]]
+[[Category: Zinc-finger]]