3i65: Difference between revisions

Revision as of 09:29, 27 March 2013

[PYRD_PLAF7] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

3i65 is a 1 chain structure with sequence from Plasmodium falciparum 3d7. Full crystallographic information is available from OCA.

Deng X, Gujjar R, El Mazouni F, Kaminsky W, Malmquist NA, Goldsmith EJ, Rathod PK, Phillips MA. Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds. J Biol Chem. 2009 Sep 25;284(39):26999-7009. Epub 2009 Jul 28. PMID:19640844 doi:10.1074/jbc.M109.028589

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-[[Image:3i65.png|left|200px]]
-<!--
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-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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 {{STRUCTURE_3i65|  PDB=3i65  |  SCENE=  }}
 ===Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM1===
+{{ABSTRACT_PUBMED_19640844}}
+==Function==
-<!--
+[[http://www.uniprot.org/uniprot/PYRD_PLAF7 PYRD_PLAF7]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
-The line below this paragraph, {{ABSTRACT_PUBMED_19640844}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 19640844 is the PubMed ID number.
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-{{ABSTRACT_PUBMED_19640844}}
 ==About this Structure==
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 ==Reference==
-<ref group="xtra">PMID:019640844</ref><references group="xtra"/>
+<ref group="xtra">PMID:019640844</ref><references group="xtra"/><references/>
 [[Category: Dihydroorotate oxidase]]
 [[Category: Plasmodium falciparum 3d7]]