2d0o: Difference between revisions

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==Overview==

The crystal structures of ADP bound and nucleotide-free forms of molecular, chaperone-like diol dehydratase-reactivating factor (DDR) were determined, at 2.0 and 3.0 A, respectively. DDR exists as a dimer of heterodimer, (alphabeta)2. The alpha subunit has four domains: ATPase domain, swiveling, domain, linker domain, and insert domain. The beta subunit, composed of a, single domain, has a similar fold to the beta subunit of diol dehydratase, (DD). The binding of an ADP molecule to the nucleotide binding site of DDR, causes a marked conformational change of the ATPase domain of the alpha, subunit, which would weaken the interactions between the DDR alpha and, beta subunits and make the displacement of the DDR beta subunit by DD, through the beta subunit possible. The binding of the DD beta subunit to, the DDR alpha subunit induces steric repulsion between the DDR alpha and, DD alpha subunits that would lead to the release of a damaged cofactor, from inactivated holoDD.

The crystal structures of ADP bound and nucleotide-free forms of molecular chaperone-like diol dehydratase-reactivating factor (DDR) were determined at 2.0 and 3.0 A, respectively. DDR exists as a dimer of heterodimer (alphabeta)2. The alpha subunit has four domains: ATPase domain, swiveling domain, linker domain, and insert domain. The beta subunit, composed of a single domain, has a similar fold to the beta subunit of diol dehydratase (DD). The binding of an ADP molecule to the nucleotide binding site of DDR causes a marked conformational change of the ATPase domain of the alpha subunit, which would weaken the interactions between the DDR alpha and beta subunits and make the displacement of the DDR beta subunit by DD through the beta subunit possible. The binding of the DD beta subunit to the DDR alpha subunit induces steric repulsion between the DDR alpha and DD alpha subunits that would lead to the release of a damaged cofactor from inactivated holoDD.

==About this Structure==

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[[Category: chaperone]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-The crystal structures of ADP bound and nucleotide-free forms of molecular, chaperone-like diol dehydratase-reactivating factor (DDR) were determined, at 2.0 and 3.0 A, respectively. DDR exists as a dimer of heterodimer, (alphabeta)2. The alpha subunit has four domains: ATPase domain, swiveling, domain, linker domain, and insert domain. The beta subunit, composed of a, single domain, has a similar fold to the beta subunit of diol dehydratase, (DD). The binding of an ADP molecule to the nucleotide binding site of DDR, causes a marked conformational change of the ATPase domain of the alpha, subunit, which would weaken the interactions between the DDR alpha and, beta subunits and make the displacement of the DDR beta subunit by DD, through the beta subunit possible. The binding of the DD beta subunit to, the DDR alpha subunit induces steric repulsion between the DDR alpha and, DD alpha subunits that would lead to the release of a damaged cofactor, from inactivated holoDD.
+The crystal structures of ADP bound and nucleotide-free forms of molecular chaperone-like diol dehydratase-reactivating factor (DDR) were determined at 2.0 and 3.0 A, respectively. DDR exists as a dimer of heterodimer (alphabeta)2. The alpha subunit has four domains: ATPase domain, swiveling domain, linker domain, and insert domain. The beta subunit, composed of a single domain, has a similar fold to the beta subunit of diol dehydratase (DD). The binding of an ADP molecule to the nucleotide binding site of DDR causes a marked conformational change of the ATPase domain of the alpha subunit, which would weaken the interactions between the DDR alpha and beta subunits and make the displacement of the DDR beta subunit by DD through the beta subunit possible. The binding of the DD beta subunit to the DDR alpha subunit induces steric repulsion between the DDR alpha and DD alpha subunits that would lead to the release of a damaged cofactor from inactivated holoDD.
 ==About this Structure==
@@ Line 24: / Line 24: @@
 [[Category: chaperone]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 18:52:25 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:54:12 2008''